prostaglandins 'n stuff

[kellysmith]

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has anyone ever come up with a good way (mnemonic or whatever) to remember the various prostacyclin/prostaglandin/thromboxane effects?

 

[omarsaleh66]

has anyone ever come up with a good way (mnemonic or whatever) to remember the various prostacyclin/prostaglandin/thromboxane effects?

prostacyclin and thrombaxane A2 are easy to remember becuase they are exact opposites of each other. Thromboxane does platelet aggregation while prostacyclin suppresses platelets.

Now think about it, if thromboxane brings platelets together, where is it released from? PLATELETS!!!

and prostacyclin doesnt want platelets all up on them, so where are they located? Endothelial cells!!!

and who cares about prostaglandins E2??, they dont work as good as prostacyclin, the only thing relevant about these is that they keep the patent ductus arteriosis open, so how do we close it?? Indomethacin!!!

later

Omar

 

[Doc Ivy]

Also remember that PGE2 mediates fever and some inflammation...that's how aspirin/NSAIDs and related meds work by blocking COX 1 and 2 the enzymes that synthesize prostaglandin

 

[adagio]

prostacyclins : imagine it as a ( cycle ) so it ( cycles the artery ) lol so it dilates it ( because u think that a circle is expanding ) , now , this lowers the pressure , likewise , if the platalets didnt aggregate , the blood will flow easily , so the pressure is still low ( e.g : its anti-aggregating )

now thromboxan is exactly the opposite ( think as it is a box well shut , so blood must struggle to get out of it thus tension is created & pressure is increased)


i hope u are not laughing at me 😀