Protein Structure

[flycd05]

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Ok so Topscore, Kaplan, and Shaum's all give different variations of what is included in the Primary, Secondary, Tertiary and Quaternary structure of a protein. This is really confusing me sooo can someone please clarify this and also tell me where u find hydrogen bonds vs disulfide bridges pleaseee?

This is my understanding, someone correct me!

Primary - basic structure of amino acids chain - determines the ultimate shape of a protein later

Secondary - alpha helix/beta sheet - uses mostly H bonds - Folding and Coiling of amino acid chain??

Tertiary - even more complex folding and coiling along with interactions with side chains - uses disulfide bridges mostly - makes up 3D protein conformation - seen in carrier proteins like myoglobin

Quaternary - final protein structure - more than one chain involved - usually in globular proteins like hemoglobin

THANKS!

 

[TheWiredNerv]

Disulfide bridges can occur in the secondary structure as well.
Quaternary structure does not have to be the final structure. Some proteins just have a tertiary structure. A better definition for quaternary is how each component of the protein interacts
There are more interactions than just H bonds and disulfides. There are polar interactions, non-polar interactions, van der waals blah blah blah.

 

[excusezmoi]

I've always thought that Secondary Structure including the motifs is mostly Hydrogen Bonding...I'm not so sure about the disulfide bridges here.
but here''s what I remember
primary -covalent peptide bond
secondary -covalent peptide & h-bonds
tertiary- h-bonds, vanderwaals, ionic bonds & disulfide....