I have some questions on antiarrhythmics.Need some help.
1.Does Na window current functions opposite of fast Na channels & K+ channels? If not, then why blocking fast Na+ & K+ channels increases AP duration (as in 1A ) and by blocking Na window current decreases AP duration (as in 1B)?
2. why "No effect in AP duration" ( mentioned in Kaplan) when class 1 C is blocking Na + channels?Don't you think, there should be increase AP duration?
3. FA 2015 says that - class 1C significantly prolongs ERP in AV node & No effect on ERP in purkinje & ventricular tissue.But, on the side, figure of ventricular AP is given. Don't you think given figure is not matching with explanation provided?
Can anybody pls explain ???Thanks.
1.Does Na window current functions opposite of fast Na channels & K+ channels? If not, then why blocking fast Na+ & K+ channels increases AP duration (as in 1A ) and by blocking Na window current decreases AP duration (as in 1B)?
2. why "No effect in AP duration" ( mentioned in Kaplan) when class 1 C is blocking Na + channels?Don't you think, there should be increase AP duration?
3. FA 2015 says that - class 1C significantly prolongs ERP in AV node & No effect on ERP in purkinje & ventricular tissue.But, on the side, figure of ventricular AP is given. Don't you think given figure is not matching with explanation provided?
Can anybody pls explain ???Thanks.
