question from a pre-med about endocannabinoids

[TinySeahorse]

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I am reading about the body's endocannabinoid system. One source states that endocannabinoids are produced in the mammillary bodies. I cannot find anything else that supports this. Are endocannabinoids hormones, neurotransmitters, or both? If they are not produced in the mammillary bodies, then where are they produced?

Additionally, they are lipophilic. Why, then, do they need cell surface receptors? Thought the pharm students might know these answers. Thanks.

 

[N U R S E]

Huh?

 

[CetiAlphaFive]

I am reading about the body's endocannabinoid system. One source states that endocannabinoids are produced in the mammillary bodies. I cannot find anything else that supports this. Are endocannabinoids hormones, neurotransmitters, or both? If they are not produced in the mammillary bodies, then where are they produced?

Additionally, they are lipophilic. Why, then, do they need cell surface receptors? Thought the pharm students might know these answers. Thanks.

No, yes, no, everywhere, you don't understand what you're asking. No.

 

[TinySeahorse]

Where are endocannabinoids produced? It's not that hard to understand what I am asking... Sorry to have stumped you??

 

[CetiAlphaFive]

Where are endocannabinoids produced? It's not that hard to understand what I am asking... Sorry to have stumped you??

Yeah, I answered you already.

Have you taken organic chemistry yet?
Have you looked up the structure of endocannabinoids yet?

Does it have 4 rings?
Do you see any interesting nitrogen?

Lastly, are you asking for any particular reason, or are you just posturing? It seems odd that someone with such seemingly in depth understanding of ligands can't immediately identify a structure's purpose by its chemical structure.

Read these and then come back.

Freund T, Katona I, Piomeli D. Role of endogenous cannabinoids in synaptic signaling. Physiology Review 2003; 83: 1017–1066

Porter A, Felder C. The endocannabinoid nervous system, unique opportunities for therapeutic intervention. Pharmacology Ther. 2001; 90:45–60

 

[TinySeahorse]

Will look into these and come back, thank you.
I am just trying to learn, no immediate reason