questions on bone formations

[alanchan]

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I am having some trouble comprehending bone formation and i need some clarification on this. Can anyone help me?? thx~~
1.)is it a must for the cartilage to be calcified before endochondral ossification?

2.) why cartilage need to be calcified??


alan

 

[FadingPromise]

By definition, bone is made up of fibers (collagen type I) and accessory glue (protegoglygans with lots of GAGs eventually making up hyalouronic acid) which are all hardened by the "hardener" such as hydroxyapatite and calcium phosphate, etc. Without approriate calcification by these hardeners, bones would mainly be left with flexible but tensile collagen fibers; in order to make the bones "hard," therefore, they have to be calcified.

It is a quick and dirty version of the full answer, but that should answer both of your questions. Hope this helps.

 

[Dirt]

By definition, bone is made up of fibers (collagen type I) and accessory glue (protegoglygans with lots of GAGs eventually making up hyalouronic acid) which are all hardened by the "hardener" such as hydroxyapatite and calcium phosphate, etc. Without approriate calcification by these hardeners, bones would mainly be left with flexible but tensile collagen fibers; in order to make the bones "hard," therefore, they have to be calcified.

It is a quick and dirty version of the full answer, but that should answer both of your questions. Hope this helps.

He is not asking why bone is calcified, but why the cartilage precursor to bone has to calcify first before endochondral bone formation can begin. The answer is...that is just the way it happens so deal.

 

[anon-y-mouse]

I am having some trouble comprehending bone formation and i need some clarification on this. Can anyone help me?? thx~~
1.)is it a must for the cartilage to be calcified before endochondral ossification?

2.) why cartilage need to be calcified??


alan

umm what are you going to ossify on? you need scaffolding first.