Applying for a second time will show that you are dedicated to pursing pharmacy, but you still have to do something to make yourself a better candidate than you were the first time around, even something as simple as applying to more or different schools.
If I dont make it in for 2006 I know its going to be because I wont have had a lot of experience (planing on finding a part time tech job starting this summer, interviews would be next feb) or recent volunteer work. So I will plan accordingly.