ranalozine

[aspiringmd1015]

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a/c to FA: inhibits later Na currents, decreasing diastolic wall tensoin and 02 consumption. wiki: inhibits na currents, which decreases intracellular ca2+(wont reach the voltage needed for opneing of ca2+ channels im assuming?) how would it decrease diastolic wall tension? and all of its SE are related to anticholinergic activity ie qt prolongated and constipation. Can anyone clear this up?

 

[aspiringmd1015]

okay, so in a uw explanatoin it says its due to inhibitting na influx, and increased activity of the na/ca exchange, so decrease ca intracellularly, decreased contraction- decreased 02 demand.