I'll share my own workflow one professional to another. I'm assuming you are a new graduate.
First off, I'll want to say that you should never trust an autorefractor completely for any patient.
Second, I don't agree at all with what optsuker wrote.
If the patient has pretty good uncorrected VAs like 20/60 or better, then I also will start around plano if I can't get any useful information from retinoscopy. I'll normally run MPBCVA sphere adjustment, power searching in all major meridians, cyl axis refinement, cyl power refinement with a +/- 0.50 JCC (my phoropter contains both 0.25 and 0.50 JCC), then I'll repeat the sequence another one or two times to see if can keep refining it. Remember your optics: you are trying to continuously collapse the CLC (circle of least confusion) on to their retina.
It may seem lengthy, but this is obviously not a normal routine patient. They need help, and they need your expertise the most. I can typically spend 20-30 min with them on just refraction alone, and I'll document it. But I've a very good record and so far in my 5 years at working at the hospital haven't had any rechecks or complaints, even though I tell these folks the most to be aware of adaptation and to return if they have problems.
After I get a good refraction, I normally will run a pentacam and send them out for cross-linking consultation if they are under 30 and I suspect keratoconus or progression on future pentacams. I also discuss contact lenses if they desire better vision then what they are afforded in my manifest phoropter.
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Now if the patient has very poor uncorrected VAs and I can't get them to do anything even with pinholes, then you can consider pentacam and fit with sclerals empirically.
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Final words of thoughts: please don't rush and rob your poor vision patients. I've seen too many doctors give very awkward results that I'm pretty sure are just Rx'd off an autorefractor. I even had a same day referral with distorted corneal mires given -2.00x3.00xWTR OU 20/40 BCVA that I got to 20/20 BCVA and they ended up like +2.00-6.00xWTR; I know the other doctor prescribes off the autorefractor because my autorefractor read the same thing.
Collapse that CLC with most plus sphere. There is a reason the refraction sequence is designed this way. There are no short cuts. I normally run the refraction sequence twice if I keep yielding more MPBCVA sphere results on my second sphere refinement.