Remodeling and Systolic Dysfunction

[nm825]

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I'm having a difficult time understanding this. Can you please see if my thinking is right? I'm going to ignore the neurohormonal aspects and just focus on the remodeling aspects.

1. There's some cause of systolic dysfunction (MI, dilated cardiomyopathy, etc)
2. Subsequently, EDV increases
3. Chronic volume overload of the left ventricle causes eccentric hypertrophy. This results in wall thinning and dilation.
4. This dilation of the ventricle results in increased wall stress and more subsequent oxygen demand and further reduction in contractility.

Does this general sequence seem right?

 

[OnePunchBiopsy]

Yup!

 

[nm825]

Yup!

So the eccentric hypertrophy ends up being maladaptive as it further decreases systolic function?

 

[OnePunchBiopsy]

So the eccentric hypertrophy ends up being maladaptive as it further decreases systolic function?

It's honestly all the factors at play that lead to the systolic dysfunction, but in a sense, yes.