Response to high pressure and volume overload in CHF

[MudPhud20XX]

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In CHF, the response to increased pressure is concentric hypertrophy, which results in thickening the wall of the heart, whereas the response to volume-overload is ventricular dilation with normal wall thickness. I get that high pressure leads to hypertrophy of the myocytes since they cannot make new cells, but how come that is not the case in volume-overload?

Is it b/c the volume-overload is not strong enough to lead to hypertrophy to thicken (hypertrophy) the wall?

Many thanks in advance.

 

[J ROD]

from what I remember it is usually caused by some type of metabolic, infectious, or toxic substance that affects the myocardium. Like alcohol, drugs (toxic), Coxsackie B, Chagas Disease (infectious), and Thyroid and even Pregnancy (metabolic)

here is the path on it. got tired of thinking...........associated with left ventricular remodeling, which manifests as gradual increases in left ventricular end-diastolic and end-systolic volumes, wall thinning, and a change in chamber geometry to a more spherical, less elongated shape. This process is usually associated with a continuous decline in ejection fraction. The concept of cardiac remodeling was initially developed to describe changes which occur in the days and months following myocardial infarction.[13]

 

[ChessMaster3000]

from what I remember it is usually caused by some type of metabolic, infectious, or toxic substance that affects the myocardium. Like alcohol, drugs (toxic), Coxsackie B, Chagas Disease (infectious), and Thyroid and even Pregnancy (metabolic)

here is the path on it. got tired of thinking...........associated with left ventricular remodeling, which manifests as gradual increases in left ventricular end-diastolic and end-systolic volumes, wall thinning, and a change in chamber geometry to a more spherical, less elongated shape. This process is usually associated with a continuous decline in ejection fraction. The concept of cardiac remodeling was initially developed to describe changes which occur in the days and months following myocardial infarction.[13]

i just want to add that in chronic volume overload eccentric hypertrophy does occur. I didnt realize concentric but not eccentric happens in CHF, if that is true, then my conclusion is that the relative pressure overload to volume overload ratio in CHF happens to be high. This would have had to be determined experimentally (ie, we couldn't have just worked it out, researchers would have to find it empirically). hope that helps and makes sense.

 

[MudPhud20XX]

Thanks a lot ChessMaster3000!

 

[J ROD]

I guess you didn't see my comment....wtf