I can't comment on too many of the northern schools, but I do know that you need to have a good reason for applying to Wake. I read through their 2011-2012 Application thread last night, and it seems like Wake favors IS/OOS about evenly (weird for a private school?) and that they realize their lower stat range will make them a safety for a bunch of people. Thus the need for good reason to apply.
I'm sure there are threads here that address this, which I'll search for later, but are we supposed to look at median or mean #'s for the most accurate representation of chances?