Both AMCAS (for MD) and AACOMAS (for DO) use a similar grid on their primary applications that looks like the below: For MD it is BCPM only vs All Others, for DO it is any science vs non-science which includes math. schools can see trends, post bacc, graduate, science vs non science, and can see trends across each academic years. How each adcom finesses this and uses it at granular level may be different. Many schools have an initial "formula" where GPA, MCAT and other factors are put in but may have different weights to them (ie GPA in 40%, MCAT is 35%, etc) and come out with an initial ranking. Others may have a more general rank cutoff for secondaries, etc. My point to all this, besides having students knowing how GPA will show up in initial applications is that trying to divine how each adcom may use your grades from rumor, innuendo, etc or how the "black box of admissions" at each school will ultimately come up with a decision does nothing but add to the obsessive compulsive stress that applicants needlessly put themselves thru. Adcoms will look at everything and targeting specific schools based any perceived advantage is like having a "system" at a casino. There is a near zero benefit in trying to do so.
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