I was also interested if there is any evidence to support intubating those with AMS so I did hte following Medline searches:
("Intubation"[MeSH] OR "Intubation, Intratracheal"[MeSH]) AND airway protection
("Intubation, Intratracheal"[MeSH]) AND aspiration prevention NOT Proseal
("Intubation, Intratracheal"[MeSH]) AND "altered mental status"
("Intubation, Intratracheal"[MeSH]) AND "CNS depression"
("Intubation, Intratracheal"[MeSH]) AND "Central nervous system depression"
("Intubation, Intratracheal"[MeSH]) AND "AMS"
aspiration AND "central nervous system depression"
aspiration AND "altered mental status"
"Pneumonia, Aspiration/prevention and control"[MeSH] AND "Central Nervous System"[MeSH]
"Intubation, Intratracheal"[MeSH] AND "intoxicated"
"Intubation, Intratracheal"[MeSH] AND "intoxication"
airway AND protection AND intoxication
airway AND protection AND intoxicated
airway AND "altered mental status"
airway AND "depressed mental status"
airway AND "depressed central nervous system"
("glascow coma score" OR "GCS") AND airway
("glascow coma score" OR "GCS") AND aspiration
And got the following articles. I reviewed about 600 abstract titles for relevance. At least for now this is likely to be something that is based more on clinical experience than evidence. The best study is the last reference, #13, that was a prospective observational study evaluating GCS and the need for intubation that identified a GCS of 8 as strongly predicting the need for intubation. I suspect this is the study that our current practice is based around. There certainly weren't any better studies identified in my search. Reference #11 is interesting. In a study of drunks, the amount of drunkeness was not predictive of developing aspiration pneumonia. In the GCS and airway reflexes study, GCS was not correlated with the presence or absence of a gag. Interesting stuff. I really need to get my hands on the article in citation #13. I suspect there may be more references there.
Comments?
Items 1 - 7 of 7
1: Rudolph SJ, Landsverk BK, Freeman ML. Related Articles, Books, LinkOut
Endotracheal intubation for airway protection during endoscopy for severe upper GI hemorrhage.
Gastrointest Endosc. 2003 Jan;57(1):58-61.
PMID: 12518132 [PubMed - indexed for MEDLINE]
2: Mercer MH. Related Articles, Books, LinkOut
An assessment of protection of the airway from aspiration of oropharyngeal contents using the Combitube airway.
Resuscitation. 2001 Nov;51(2):135-8.
PMID: 11718968 [PubMed - indexed for MEDLINE]
3: Paventi S, Liturri S, Colio B, Santevecchi A, Ranieri R. Related Articles, Books, LinkOut
Airway management with the Combitube during anaesthesia and in an emergency.
Resuscitation. 2001 Nov;51(2):129-33. Retraction in: Paventi S, Liturri S, Santevecchi A, Ranieri R. Resuscitation. 2002 Sep;54(3):317.
PMID: 11718967 [PubMed - indexed for MEDLINE]
4: Tayal VS, Riggs RW, Marx JA, Tomaszewski CA, Schneider RE. Related Articles, Books, LinkOut
Rapid-sequence intubation at an emergency medicine residency: success rate and adverse events during a two-year period.
Acad Emerg Med. 1999 Jan;6(1):31-7.
PMID: 9928974 [PubMed - indexed for MEDLINE]
5: Asai T. Related Articles, Books, LinkOut
Editorial II: Who is at increased risk of pulmonary aspiration?
Br J Anaesth. 2004 Oct;93(4):497-500. No abstract available.
PMID: 15361474 [PubMed - indexed for MEDLINE]
6: Oswalt JL, Hedges JR, Soifer BE, Lowe DK. Related Articles, Books, LinkOut
Analysis of trauma intubations.
Am J Emerg Med. 1992 Nov;10(6):511-4.
PMID: 1388374 [PubMed - indexed for MEDLINE]
7: Redding JS, Tabeling BB, Parham AM. Related Articles, Books, LinkOut
Airway management in patients with central nervous system depression.
JACEP. 1978 Nov;7(11):401-3.
PMID: 45681 [PubMed - indexed for MEDLINE]
8: Michael H, Harrison M. Related Articles, Links
Best evidence topic report: endotracheal intubation in gamma-hydroxybutyric acid intoxication and overdose.
Emerg Med J. 2005 Jan;22(1):43. Review.
PMID: 15611542 [PubMed - indexed for MEDLINE]
9: Vadeboncoeur TF, Davis DP, Ochs M, Poste JC, Hoyt DB, Vilke GM. Related Articles, Links
The ability of paramedics to predict aspiration in patients undergoing prehospital rapid sequence intubation.
J Emerg Med. 2006 Feb;30(2):131-6.
PMID: 16567245 [PubMed - in process]
10: Davis DP, Vadeboncoeur TF, Ochs M, Poste JC, Vilke GM, Hoyt DB. Related Articles, Links
The association between field Glasgow Coma Scale score and outcome in patients undergoing paramedic rapid sequence intubation.
J Emerg Med. 2005 Nov;29(4):391-7.
PMID: 16243194 [PubMed - indexed for MEDLINE]
11: Christensen MA, Janson S, Seago JA. Related Articles, Links
Alcohol, head injury, and pulmonary complications.
J Neurosci Nurs. 2001 Aug;33(4):184-9.
PMID: 11497070 [PubMed - indexed for MEDLINE]
12: Moulton C, Pennycook AG. Related Articles, Links
Relation between Glasgow coma score and cough reflex.
Lancet. 1994 May 21;343(8908):1261-2.
PMID: 7910279 [PubMed - indexed for MEDLINE]
13: Chan B, Gaudry P, Grattan-Smith TM, McNeil R. Related Articles, Links
The use of Glasgow Coma Scale in poisoning.
J Emerg Med. 1993 Sep-Oct;11(5):579-82.
PMID: 8308236 [PubMed - indexed for MEDLINE]