SNPs: a thread not about programs and applications

[PathJet]

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sorry i am a bit unimganitive today and have been thinking a lot about testing lately especially testing based on genetic variations in the population vis a vis pharmacogenomics

..but anyway TGIF!!


"warfarin resistance testing" --seems to be representing new directions in lab testing pharmacogenomics and what not



WWYD? 👎 or 👍

 

[DarksideAllstar]

sorry i am a bit unimganitive today and have been thinking a lot about testing lately especially testing based on genetic variations in the population vis a vis pharmacogenomics

..but anyway TGIF!!


"warfarin resistance testing" --seems to be representing new directions in lab testing pharmacogenomics and what not



WWYD? 👎 or 👍

We had some PhD clinical chemist here show us all this "pharmacogenomics" data, in particular for warfarin. The thing that amazes me (and this is through hearsay) is that this will be mandatory for people who will be on warfarin, but we have no idea whatsoever it will change clinical outcomes (ie morbidiy/mortality associated with warfarin over/under dosages). There are so many variables that contribute to whether someone's INR fluctuates (diet, other meds, supplements), I don't expect this to change things that much. I haven't looked into this personally, so someone correct me if I have misstated. I am making the assumption that this guy would have shown us outcomes data if it were available.

 

[b&ierstiefel]

😴😴😴

I'm glad Boston College lost to FSU. That team was way overrated.

 

[PathJet]

We had some PhD clinical chemist here show us all this "pharmacogenomics" data, in particular for warfarin. The thing that amazes me (and this is through hearsay) is that this will be mandatory for people who will be on warfarin, but we have no idea whatsoever it will change clinical outcomes (ie morbidiy/mortality associated with warfarin over/under dosages). There are so many variables that contribute to whether someone's INR fluctuates (diet, other meds, supplements), I don't expect this to change things that much. I haven't looked into this personally, so someone correct me if I have misstated. I am making the assumption that this guy would have shown us outcomes data if it were available.

its not mandatory yet
but the FDA did change the label of the drug recently to inform physicians and patients about the genetic tests

 

[docbiohazard]

It seems like if the outcomes data was lacking, after awhile the insurance companies would wise up and refuse to pay for it. Medicare as well. Assuming they pay for it in the first place...

This reminds me of the "functional nutritional assay" that I mentioned in another thread, culturing lymphocytes with different nutrients in a defined media w/ mitogen stimulation and somehow relating variable proliferation rates to actual nutritional deficiencies. No actual outcome data that I can find... surprised any insurance pays for it (few do...)

BH

 

[SexiMexi]

😴😴😴

I'm glad Boston College lost to FSU. That team was way overrated.

FSU = #1

 

[PathJet]

um sorry guys FSU is not number 1



and there are prospective trials which point to a decrease in minor bleeding events other trials should be coming out in the next year or so to attempt to look at major bleeding events --

i have also heard people saying it is difficult to get insurance companies to pay for these tests i guess like other preventative medicine tests
do they pay for the cardiac score CT?

 

[SexiMexi]

Whatever PathJet...they're #1 in my heart!