Step 1 help

[weightlifter911]

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How are you guys going about memorizing the CYP450 enzymes for specific drugs?

 

[johndoe3344]

You mean the specific isoforms? You don't.

 

[lrkoehle]

You mean the specific isoforms? You don't.

Agreed. Maybe just know the most common one? Isn't is like 3A4? Something like that.

 

[weightlifter911]

my friend who recently took it said she had two questions... so I diidnt know if there was a quick mnemonic

 

[lrkoehle]

my friend who recently took it said she had two questions... so I diidnt know if there was a quick mnemonic

Not that I'm aware of. That's ridiculous that they'd have that on there...then again, I'm sure people have been saying that about Step-I for years.

 

[The kitchen sink]

my friend who recently took it said she had two questions... so I diidnt know if there was a quick mnemonic

dayumm

 

[TooMuchResearch]

Not that I'm aware of. That's ridiculous that they'd have that on there...then again, I'm sure people have been saying that about Step-I for years.

It's a test of things we will likely never see, so that sounds about right

 

[AndyRSC]

Specific P450 enzymes aren't tested on step I, unless part of an experimental question. She was likely talking about P450 interactions of different drugs in general. There are, in fact, very handy menmonics for this (Queen Barb + beer from a KEG) towards the end of the pharm section in FA. This is high-yield and you will very likely have a question or two on this.

 

[Morsetlis]

I still have PTSD from my Genetics final this morning.

2E1 for ethanol, acetaminophen to toxic NAPQI
2D6 for codeine, antidepressants
2C9 for warfarin (vitamin K epoxide reductase inh), also polymorphic with VKORC1
3A4 inhibition by grapefruit

 

[missmedschool]

How are you guys going about memorizing the CYP450 enzymes for specific drugs?

Memorizing specific isoforms is very low yield ... just know the drugs that inhibit or induce. 99% of the time the problem will give you the isoform & you have to figure out if the drug inhibits or induces.

 

[The kitchen sink]

Memorizing specific isoforms is very low yield ... just know the drugs that inhibit or induce. 99% of the time the problem will give you the isoform & you have to figure out if the drug inhibits or induces.

are you saying PICK EGS is sufficient enough?

 

[mdeast]

Memorizing specific isoforms is very low yield ... just know the drugs that inhibit or induce. 99% of the time the problem will give you the isoform & you have to figure out if the drug inhibits or induces.

Agreed. Don't waste your time on this. Just know which drugs change (inhibit or induce) and how this might be clinically relevant given drug interactions (i.e. warfarin ineffectiveness, or that protease inhibitors increase the potency of other HIV drugs, etc.).

 

[johndoe3344]

are you saying PICK EGS is sufficient enough?

PICK EGS
BCG PQRS

And a few random ones here and there (e.g. valproate) not covered by the two mnemonics is all that I'm going to know about CYP450's