Suzetrigine

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Is this just fancy lamotrigine? Their mechanisms sound similar. Maybe more specificity for certain Na channels? Pain score reductions do sound impressive, and it obviously got approved. Curious where it'll show up first. At the VA, we'd often get things like this immediately after approval. $15/pill doesn't sound too crazy.
 
cchoukal said:
Is this just fancy lamotrigine? Their mechanisms sound similar. Maybe more specificity for certain Na channels? Pain score reductions do sound impressive, and it obviously got approved. Curious where it'll show up first. At the VA, we'd often get things like this immediately after approval. $15/pill doesn't sound too crazy.
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But the hospitals will charge $1500.

It looks like a blocks a specific Na+ channel only on peripheral peripheral nerves with no adverse CNS or cardiac effects. I'm intrigued.
 
I’m at a meeting this weekend. Spoke to a vertex rep. He said FDA trial used norco as active comparator for bunions and abdominoplasty. New drug was comparable to norco so nothing game changing yet. Maybe dose finding studies will show more impressive results.
 
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nimbus said:
I’m at a meeting this weekend. Spoke to a vertex rep. He said FDA trial used norco as active comparator for bunions and abdominoplasty. New drug was comparable to norco so nothing game changing yet. Maybe dose finding studies will show kore impressive results.
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I don’t know.
I think that’s pretty remarkable personally and will def change my practice.
I personally do not prescribe anything over 50 med for chronic non malignant refractory pain and the main stays are tramadol and/or Vicodin
For me it will be pretty important
 
cchoukal said:
I don’t know, comparable to Norco without any of the side effects? That seems like something worth talking about.
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AKMD_1984 said:
I don’t know.
I think that’s pretty remarkable personally and will def change my practice.
I personally do not prescribe anything over 50 med for chronic non malignant refractory pain and the main stays are tramadol and/or Vicodin
For me it will be pretty important
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Yeah I was looking through my siloed anesthesia lens where I didn’t think it was a big deal to send a bunion patient home with 5 Norcos. Can see how it might make a bigger difference in other settings.
 
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abolt18 said:
Pretty exciting. Lots of potential. Gonna cost a lot of money till the patent runs out which will severely limit use I suspect.

Also curious how much those sodium channel blockers interact with the heart's sodium channel.
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I read about this earlier today. It selectively targets a certain sodium channel found in pain neve fibers. Doesn't affect other sodium channels. I think it's only available PO.
 
The clinical benefits were small. I'm thinking this is more likely to be closer to gabapentin without the respiratory/cognitive issues. Part of the multimodal stuff with a unique-ish mechanism, but not a game changer by itself.
 
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