SVZ-NPC-GBM axis

[Scatter]

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Thought-provoking, even if a stretch. Dr. Iris Gibbs has a way with words -- good read.

http://www.sciencedirect.com/science/article/pii/S0360301613002630

 

[Palex80]

-"You have to treat this region!"
-"But this is where I am causing all the damage, that's the region I want to spare out!"
-"You have to treat this region!"
-"Damm!"

On a side note, I don't buy this hypothesis. Early GBM trials did WBRT to 50-60 Gy and still survival sucked. So even if these were the regions, where tumor stell cells arose from, wouldn't the WBRT fry them?

 

[Scatter]

-"You have to treat this region!"
-"But this is where I am causing all the damage, that's the region I want to spare out!"
-"You have to treat this region!"
-"Damm!"

On a side note, I don't buy this hypothesis. Early GBM trials did WBRT to 50-60 Gy and still survival sucked. So even if these were the regions, where tumor stell cells arose from, wouldn't the WBRT fry them?

Grasping at straws, I suppose. After all, we've barely made any progress in the last 50 years (not sure if 2 months is progress ...) in GBM, so anything that might lead down a path to prolonged survival is enticing.

On a side note, get yourself one of these! I got one! http://www.amazon.com/Dammit-Doll-V12151/dp/B007WFSGMU

"For those days when nothing goes right and you want to hit the wall, your Dammit Doll is always on call."

 

[rymd]

And a "propitious proposition that promises prosperous progress" would be to write all scientific papers with such FLAIR. It'll help attenuate the noise, and allow for recovery of the message that matters!

 

[thesauce]

Grasping at straws, I suppose. After all, we've barely made any progress in the last 50 years (not sure if 2 months is progress ...) in GBM, so anything that might lead down a path to prolonged survival is enticing.

I agree that 2 months isn't a home run, but I think the real benefit was the tail on the survival curve (i.e. the first real evidence of long-term survival). Not sure it was ever successfully reproduced though.

 

[Brim]

I agree that 2 months isn't a home run, but I think the real benefit was the tail on the survival curve (i.e. the first real evidence of long-term survival). Not sure it was ever successfully reproduced though.

The "tail" on the survival curve is laughable if you look at the number of pts at risk (printed under the graph).

 

[thesauce]

The "tail" on the survival curve is laughable if you look at the number of pts at risk (printed under the graph).

I do see what you mean:
39 vs 11 at 3 years
23 vs 6 at 4 years
14 vs 3 at 5 years
6 vs 0 at 6 years

 

[RadOncDoc21]

I do see what you mean:
39 vs 11 at 3 years
23 vs 6 at 4 years
14 vs 3 at 5 years
6 vs 0 at 6 years

So you're telling me there's a chance?

 

[thesauce]

So you're telling me there's a chance?

What was all that one in a million talk?

 

[RadOncDoc21]

I know there's always a chance, just curious does anyone ever use the word cure anymore? I cringe whenever I hear that word even if I saw a DCIS patient 20 years out. I have to say GBM's are more satisfying to see compared to unresectable pancreatic cancer.

 

[deleted4401]

The recurrence rate after RT after DCIS is quite low. I don't say cure but I do say "I don't expect to see this ever come back". Which is reasonable to say, when you lower someone's risk of recurrence from 30 percent to 10 percent. It's unlikely, and so you can tell them that.

On the other hand, with lung, pancreas, esophageal and others.. The best thing to say is that "I hope we can keep this at bay, but they tend to come back. If that happens, we will figure out what to do next"

 

[Palex80]

"curative intention" is what I use...
😛