TCAS pregnancy category C or D

[Scorcher31]

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Hey guys doing a review on all antidepressants and anxiolytics for a psychopharm course. Most of the pubmed articles I am reading are supporting Nortriptyline over Amitriptyline due to less anticholinergic effects and less potential for hypotension and sedation. What I noticed however is that all the TCAS are pregnancy category C except Imipramine and Nortriptyline which are D. Does anyone have any idea why. Perhaps these were the 2 that were initally studdied when TCAS were thoguht to have a higher rate of limb malformations and despite more recent evidence to the contrary the categories have stuck?

 

[Scorcher31]

Even more confusing if nortryp is the active metabolite of amitryp it would only make sense if amitryp was category d and nortryp was category c. If amitryp is category C it makes nortryp a category D so by default wouldn't that make amitryp a cateogry D.