The "Polypill"

[WVUPharm2007]

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It totally cracks me up that somebody actually went ahead and did this. Albeit, this is in India...

Methods

In a double-blind trial in 50 centres in India, 2053 individuals without cardiovascular disease, aged 45–80 years, and with one risk factor were randomly assigned, by a central secure website, to the Polycap (n=412) consisting of low doses of thiazide (12·5 mg), atenolol (50 mg), ramipril (5 mg), simvastatin (20 mg), and aspirin (100 mg) per day, or to eight other groups, each with about 200 individuals, of aspirin alone, simvastatin alone, hydrochlorthiazide alone, three combinations of the two blood-pressure-lowering drugs, three blood-pressure-lowering drugs alone, or three blood-pressure-lowering drugs plus aspirin. The primary outcomes were LDL for the effect of lipids, blood pressure for antihypertensive drugs, heart rate for the effects of atenolol, urinary 11-dehydrothromboxane B2 for the antiplatelet effects of aspirin, and rates of discontinuation of drugs for safety. Analysis was by intention to treat.

......and so on.

Right now its just billed as a means to save developing countries from heart disease. Like a sort of broad spectrum cradiopharmacotherapy. But I got to ask...so how long until we see the thiazide/betablocker/ace-i/statin/asa combo drug on pharmacy shelves? Brilliantly combining a bunch of generic drugs into a brilliant new brand-only combo drug of innovation!

 

[stevephhs016]

Hmm...that actually has a real good market opportunity. I'm sure though we will have generic companies fighting for competition.

But that trial is a head start.

 

[Aznfarmerboi]

It totally cracks me up that somebody actually went ahead and did this. Albeit, this is in India...



Right now its just billed as a means to save developing countries from heart disease. Like a sort of broad spectrum cradiopharmacotherapy. But I got to ask...so how long until we see the thiazide/betablocker/ace-i/statin/asa combo drug on pharmacy shelves? Brilliantly combining a bunch of generic drugs into a brilliant new brand-only combo drug of innovation!

Not long... it can be marketed like how they did with vitamins. Did you catch the commercials where they went... D enhances the absorption of Calcium, E enhanes.. blah blah blah. Potassium sparing balances out the ACEI, BB works together with the CCB, blah blah.

 

[Quiksilver]

patient compliance should increase at least. Still gotta love those drug companies that reinvent the wheel

 

[ItsOverZyvox]

Sean Connery: Alex, I will take "POLYP ILL" for $1,000.....

Alex Trebek: That's "POLY PILL"

Sean Connery: Trebek...your mother is a *****..

 

[RxWildcat]

Sean Connery: Alex, I will take "POLYP ILL" for $1,000.....

Alex Trebek: That's "POLY PILL"

Sean Connery: Trebek...your mother is a *****..

YES! haha

 

[ItsOverZyvox]

Just in case for people who have no idea what I'm talking about...

[YOUTUBE]http://www.youtube.com/watch?v=pcp439tno-s&feature=related[/YOUTUBE]

 

[codep1nk]

treat the patient, not the disease?

too much variability in patients.

 

[ffpickle]

haha Colbert covered this on his show and outdid them with Ultramaxavax or something like that...pretty funny bit.

 

[ItsOverZyvox]

Sean Connery: I'll take Anal Bum Cover for $1,000.

Alex Trebek: That's "An Album Cover"

 

[ItsOverZyvox]

Japan US Relations

[YOUTUBE]http://www.youtube.com/watch?v=I6dsmx8YmPs[/YOUTUBE]