Those darn PPAR agonists do it again....

[WVUPharm2007]

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First PPAR-alpha wowed us with the cholesterol lowering wonders of Tricor, then PPAR-gamma came along and started making insulin work better...now....

PPAR-delta makes 'em all look silly.

By giving ordinary adult mice a drug - a synthetic designed to mimic fat - Salk Institute scientist Dr. Ronald M. Evans is now able to chemically switch on PPAR-d, the master regulator that controls the ability of cells to burn fat.

Even when the mice are not active, turning on the chemical switch activates the same fat-burning process that occurs during exercise. The resulting shift in energy balance (calories in, calories burned) makes the mice resistant to weight gain on a high fat diet.

The hope, Dr. Evans told scientists attending Experimental Biology 2007 in Washington, DC, is that such metabolic trickery will lead to a new approach to new treatment and prevention of human metabolic syndrome. Sometimes called syndrome X, this consists of obesity and the often dire health consequences of obesity: high blood pressure, high levels of fat in the blood, heart disease, and resistance to insulin and diabetes.

LINK

That's crazy go nuts, folks. This particular drug may not make it, but it gives us some hope for some very interesting possibilities in the future. Imagine the implications of a PPAR-delta agonist in humans. Could it lead to the end of obesity? What about type 2 diabetes? Hypertension? Estrogen-dependent cancers? Could I in fact be one day getting a metabolic workout while sitting on my ass playing Gears of War of Super Paper Mario?

And just imagine the aesthetics of it all - no more fat people. Anywhere. There would be 3 times as many hot women running around. Oh, bless the future....and bless that sweet, sweet peroxisome proliferator-activated receptor....

 

[ZpackSux]

Barking up the wrong tree. You need to modulate Insula in the CNS to control the craving... when we learn to do that..we can control addictions such as smoking..food...etc.

 

[WVUPharm2007]

They fed the rats a high-fat diet during the test period. It might render all of that less important, Z. (I won't say meaningless, if you ate 45 tubs of Crisco a day, nothing is going to help you....)

 

[Requiem]

Hey WVU,

I've got 4 weeks of work this summer, but once that's done I think I might crave and buy an XBOX 360 with NHL 2k7 and GoW.

What are your thoughts on the system?

 

[WVUPharm2007]

It's great for multiplayer online. Def. get Gears. It's good stuff. A Wii is better for multiplayer with actual, physical friends.

 

[Requiem]

It's great for multiplayer online. Def. get Gears. It's good stuff. A Wii is better for multiplayer with actual, physical friends.

What are these "physical" friends??

That's why i'm getting 2k7 to be honest, all of my friends like hockey games and it's fun to play while pregaming before a mixer or something. Cheers.

 

[WVUPharm2007]

If you are getting it for friends you know in real life, the Wii is honestly the best option. That **** is a blast. Me and my friends have wasted hours of life playing that ****.

See, look at us all having fun. It's fun as hell to laugh at them while they are playing. That's my friend Lovins playing, another friend, Andrew, sitting on a giant blue ball, and the wife video taping it all. I have no idea where the hell I am. Probably mixing that lush Lovins another Long Island Iced Tea....

 

[Requiem]

Hahah it looks good. I clicked the link and thought you just linked to some random people, then I heard this southern accent and realized oh it's probably him. I swear I thought your wife was just someone's little brother; better for her to have a little boys voice than a man's I suppose

Seems like it's definitely a good purchase, but I think another one of my friends might be getting it too though. I think the XBOX would be better if I just wanna play something at 2AM in the morning.

Halo 3 looming in the distance is a bonus too.

 

[WVUPharm2007]

The pluralization of "you ones" is an interesting thing in these neck of the woods.

'Ol Danny's accent is different than mine (Dude playing in the WVU hoodie.) He grew up in Huntington WV, he has a Kentuckyish-lite twang. He says y'all.

Andy, the bearded dude, is from Southern WV, his accent is more North Carolina-Maryland hybrid. He says "you guys" like a damned Yankee. (He's just good at covering up the accent)

I'm from Parkersburg, WV. I sound like a mix between Pittsburgh, Midwestern, and Southern. I say "yall's". It rhymes with gauze. I have no idea where I am in the video though.

The wife is from Philly, she says "You's" like a Jersey gangster.

Then I have another friend we hang out with who is from Pittsburgh who says "Yinz."

It's actually quite an interesting mix of dialect when we are all together.