titers

This forum made possible through the generous support of SDN members, donors, and sponsors. Thank you.

foofighter7

Member
15+ Year Member
Joined
Jun 2, 2005
Messages
101
Reaction score
6
So while reading MTB and doing some uworld, i got confused with this whole titers deal when talking about RH sensitization. Can anway explain the whole 1:4 vs 1:16 stuff.

Thanks
 
From Wikipedia:

An antibody titer is a measurement of how much antibody an organism has produced that recognizes a particular epitope, expressed as the greatest dilution that still gives a positive result. ELISA is a common means of determining antibody titers.

For example, the indirect Coombs test detects the presence of anti-Rh antibodies in a pregnant woman's blood serum. A patient might be reported to have an "indirect Coombs titer" of 16. This means that the patient's serum gives a positive indirect Coombs test at any dilution down to 1/16 (1 part serum to 15 parts diluent). At greater dilutions the indirect Coombs test is negative. If a few weeks later the same patient had an indirect Coombs titer of 32 (1/32 dilution which is 1 part serum to 31 parts diluent), this would mean that she was making more anti-Rh antibody, since it took a greater dilution to abolish the positive test.
 
Top