Are you using Topamax instead of Naltrexone in AUD cases preferentially? Combining them? Or after failing naltrexone/Vivitrol?
I think it's a pretty underwhelming medication beyond it's carbonic anhydrase inhibition but I wonder how much of that is regional, as I never saw it prescribed psychiatrically at any of the sites I did medical school, residency, or fellowship at.
Topiramate is rarely my first choice, but is definitely something I use for a variety of conditions.
For one, its an effective migraine medication for someone with comorbid migraines that for whatever reason no one has bothered to offer prophylactic meds ("I've only been given NSAIDs and triptans before... what's a prophylactic med?").
Second it was well established in weight loss prior to GLP-1s, and I'll usually use it after failure of metformin for the antipsychotic induced metabolic effects. Most patients describe it as changing the taste of things (like soda doesn't take sweet anymore). Also helpful for BED.
Third, I often use it after intolerance/failure of prazosin for PTSD associated nightmares.
Fourth, its a reasonable nth line option for AUD, after the typical trials of naltrexone or acamprosate fail or aren't tolerated. Also use in combination with some first line items. I group it, baclofen, gabapentin, etc. together as a "they kind of work for some people" group.
I will also rarely use it for bad BPD, but can maybe think of only a handful of times, where maybe 2 found it helpful.
It was often used where I trained, and where I am now, tends to be used mostly just for weight loss.
The cognitive blunting effect is dose-dependent and often happens at higher doses of 400mg or above. I tend not to go above 150mg and it's been really helpful for my patients with
alcohol use disorder to cut down on drinking, those on antipsychotics to reduce cravings. I feel the cognitive dulling is similar to what I see with patients on pregabalin/gabapentin at the higher doses. I don't see cognitive dulling at doses of 25-100mg and in fact, people tell me they are able to think more clearly with less anxiety, better sleep, less alcohol use, etc. Topiramate is one of these paradoxical drugs that can help and cause issues with cognition, depression, and even psychosis.
There is a meta analysis of 12 RCTs for topiramate for schizophrenia which shows some efficacy for both positive and negative symptoms:
Efficacy and tolerability of topiramate-augmentation therapy for schizophrenia: a systematic review and meta-analysis of randomized controlled trials - PubMed
It's also been studied in OCD, bulimia/binge eating, cocaine/meth use disorders, PTSD, borderline personality disorder. It doesn't work as an antimanic agent though.
I would agree with regards to the cognitive dulling. It usually is not significant until above 100 mg in my experience, but it happens regularly enough that I always mention it as a potential adverse effect.
Its funny, I stumbled upon that article like a week ago when I was looking for something else.
As are most medications. Early elderly like 65-75 yo there's data, but good luck finding solid data on treating almost anything in patients 80yo+. One of my IM attendings in med school was geri boarded and he said that the data for pretty much everything after 75 is weak at best and after 85 yo is basically garbage. Honestly, at that point I'm only really concerned with maintaining quality of life and acute mortality risks, part of why I've always disliked geriatric medicine and psych.
To be completely honest, my goals for the >75 population is almost always "less is more" and deprescribing. Its very rare that I see someone in that age group that truly needs "more" meds, unless we are dealing with dementia related behavioral disturbance.
Primary concern I've heard for stimulants during pregnancy is HTN/pre-eclampsia in patients at risk. I'll double check with the academic repro psychiatrists I work with, but I believe they continue stimulants for patients with ADHD who have been stable on them long-term.
Yes, this is definitely a concern, especially in the cHTN (aka just HTN...) and at risk cHTN population.