Generally, it is quite difficult to transfer, but it CAN be done even without having a spouse, etc in that state. I am from IN, but did my first two years on the east coast. I absolutley HATED living on the east coast, and I knew I could not stand another two years out there. I essentially went there in the first place because my family was a total circus and needed to get away. I was able to transfer to IU School of Medicine between 2nd and 3rd year, which by the way is the best decision I have ever made. I presented the fact that I had no financial support from any family and the cost was killing me in NY, that I had every intention of returning to the Midwest upon graduation (and I still intend to stay here), and I also told the deans what I liked better about IU as compared to my previous school. I made sure that I was familiar with the curriculum when I had an interview with the deans. I presented all of this in a letter with my application. I also may have had an advantage in that I knew one of the deans from my original interview.
If you want to transfer, start on it early. Contact the dean of admissions ASAP and inform them of your desire to transfer and how to proceed. I would be very proactive about it, offer to do another interview with them over the Christmas break. I think the key is to show a sincere desire to transfer AND that it would benefit you (as an example I was beyond miserable in NY). If accepted for transfer, you will probably have to wait until the school gets your Step 1 scores to start 3rd year. I started a month behind and have to take family medicine during 4th year. Sure it is a little pain in the butt, but I am more than grateful to IU for allowing me to transfer and have no problem with less vacation 4th year. And I had no problem starting all over and only knowing like 2 people.
Also, not trying to bash living in New York, I know it is fine for a lot of people, but if you aren't one of those people it really sucks.