Triglyceride Digestion

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BriannaWV

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I have my Animal Nutrition final tomorrow and I was hoping someone here would be able to help me figure this thing out! I am 99% sure this is going to be on my final and I can't find it anywhere in my notes and whatnot.

I need to know how triglycerides are digested in monogastric animals, starting with consumption and ending with the cecum/large intestine. I need to include certain words (this was on a test before but he went too fast so I only wrote down the words he stressed), I just don't know what roles they play.

So far I have that a triglyceride is consumed, pancreatic lipase turns it into 2 free fatty acids and a monoglyceride.


I need to use "bile", "intestinal lipase" and "salivary lipase".

Any help would be nice!!!
 
cowgirla said:
Google is your friend. Quick search just brought up a half dozen websites that look good and accurate.
Click to expand...

I literally searched Google for an hour plus now and I can't find ANYTHING that puts it all together. I found some PDFs that looked rather helpful and that's where I got the stuff I know from, but other than that I have had no luck.

Which is why I ended up posting here for help...
 
Here is a brief synopsis that is probably more than you want, but still simple enough that it isn't insane:

Salivary Lipase begins breakdown of triglycerides. Stomach contractions emulsify ingested fat. The fat entering the duodenum stimulates CCK release by enteroendocrine cells. CCK stimulates gall bladder contraction and secretion of pancreatic enzymes and CCK stimulates eneropeptidase secrtetion which will allow activation of Pro-CoLipase to CoLipase. CoLipase together with Lipase and Bile salts act upon emulsified fat to begin triglyceride breakdown to monoglycerides and fatty acids. Micelles are then formed. Micelles contact the brush border membrane. Brush border bound intestinal Lipase converts any monoglycerides to glycerol and fatty acid. Fatty acids, cholesterol and glycerin, and fat soluble vitamins cross into cytosol. Triglycerides are reformed and packaged in cholesterol-apolipoprotein B48 structers known as chylomicrons. Chylomicrons pass thru the basolateral membrane and enter the lacteals.....


That should do it!
 
Here goes - hope this helps...(anyone else feel free to edit/make corrections...)

Mouth = mastication and lingual lipase starts digestion by cleaving fatty acid chains from glycerol (3 carbon backbone)

Stomach - have some mechanical action which increases surface area and food stimulates the hormone gastrin that stimulates gastric lipase which also cleaves free fatty acids from glycerol
-pyloric sphincter measures fat droplets

Duodenum - food stimulates secretin that stimulates pancreatic secretions such as bicarbonate that increases the pH so enzymes can function and pancreatic lipase
-CCK is stimulated that causes bile release from the gall bladder and/or liver that emulsifies fat or makes it into smaller soluble product
-from the duodenal mucosal cells gastric lipase is secreted which is the only lipase I believe that is nonspecific and cleaves off the fatty acid chains
-also you have colipase from the pancreas that protects lipase from being digested by other intestinal enzymes

jejunum - absorbtion where inside the intestinal cells free fatty acids chains and glycerol are converted back to triglycerides and transported through lymphatics as chylomicrons

ileum - some bile salts are absorbed

large intestine - some microbial fermentation of lipids that escaped through, not a lot does because too much fat can be toxic to microbes and any nutrients from escape fats will only be absorbed if the animal practices caprophagy (eating its one feces) since absorbtion of fats only occurs in the small intestine - example is bunny rabbits 🙂
 
Thanks everybody!!! You all really helped me! I appreciate it very much! 🙂
 
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