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Started by Husseinmr
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Husseinmr

New Member
10+ Year Member
Hello ,this is my first post,i am immigrating to Canada next summer and i am preparing for the PEBC ,i started with calculations (it wasn't good idea after all) ,well after 3 days of study(3 hours per day) i can say i have the basics now ,but this question below i don't know what they want so if anyone can help not by giving the final answer but how he understand it it will be great,by the way my e mail is [email protected] if any one wants to share some PEBC information

question: for children,streptomycin is to be administered at a dose of 30 mg/kg of body weight daily in divided doses every 6-12 hr. the dry powder is dissolved by adding water for injection,USP in an amount to yield the desired concentration as indicated in the following table(for a 1 g vial)
approximate concentration(mg/ml) volume
200 4.2
250 3.2
400 1.8
reconstituting at the lowest possible concentration,what volume in ml would be withdrawn to obtain one day's dose for a 50-lb child?
a- 3.4 ml b- 22.73ml c- 2.50 ml d- 2.27 ml
 
The daily dose is 30mg/kg and the patient weight is 50lb.

50lb/2.2lb=22.7kg (2.2lb=1kg)

22.7kg*30mg/kg=682mg/day

Need to use the lowest concentration per the question, so 200mg/4.2ml

682mg/200mg per ml=3.41ml

I would say the answer is A

Hope this helps