usmle mcq on collagen

[absolutjag9]

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Radiographic studies of a 65-year-old man with chronic hip pain reveal marked narrowing of the space between the femur and the hip socket. The patient is surgically treated with removal of the proximal femur and replacement with a prosthesis. Gross examination of the femoral head shows loss of much of the joint cartilage and multiple tiny clefts in the remaining cartilage. The disease process that produces this joint abnormality is thought to be related, in part, to proteolytic attack on which of the following types of collagen?

A. Collagen type I
B. Collagen type II
C. Collagen type III
D. Collagen type IV
E. Collagen type V

i initially thought A but if they are asking about joint degradation...would it be B?

 

[rahulb]

yes type II collagen -> cartilage

 

[EBI831]

Since it's describing osteoarthritis and this is a process that affects articular cartilage (evidence in the vignette describing fibrillations etc), I would say B : type II collagen.

 

[NCF145]

It is B

 

[Jccripe]

Car-2-lage...sorry i couldn't help myself

 

[Chinorlz]

Car-2-lage...sorry i couldn't help myself

that's how I remember it too😀

 

[Entgegen]

Car-2-lage...sorry i couldn't help myself

That's awesome! Thanks!