UW immun q

[MudPhud20XX]

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Hi all, can anyone explain this q please?

A 6 yr old immigrant from Eastern Europe is brought to the emergency dept by his parents after they found him having difficulty breathing. The child has a fever and has not been eating or drinking for the last several hours. Head and neck exam reveals neck swelling, palatal paralysis, and a gray pharyngeal exudate. The parents are unable to provide information regarding the child's vaccination hx. Which of the following interventions is most likely to improve this pt's prognosis?

A. antibiotic therapy
B. active immunization
C. passive immunization
D. adequate hydration
E. anti-inflammatory medications

I got this one right, but still don't get it.

A healthy 6 day old baby girl is brough to the office for her first well baby checkup. This is the mother's second child. She was born full term, with a birth weight of 4200 grams and a length of 51 cm. APGAR scroes were 8 at 1 min and 9 at 5 min. She was recently discharged from the well baby nursery 3 days ago. The baby's blood type is A negative while the mother is B negative. High circulating levels of anti-A antibodies are found in the mother's blood. Hemolysis did not occur in the baby b/c these maternal antiboides are most likely of which class?

A. IgA
B. IgD
C. IgE
D. IgG
E. IgM

 

[dfib slim]

Hi all, can anyone explain this q please?

A 6 yr old immigrant from Eastern Europe is brought to the emergency dept by his parents after they found him having difficulty breathing. The child has a fever and has not been eating or drinking for the last several hours. Head and neck exam reveals neck swelling, palatal paralysis, and a gray pharyngeal exudate. The parents are unable to provide information regarding the child's vaccination hx. Which of the following interventions is most likely to improve this pt's prognosis?

A. antibiotic therapy
B. active immunization
C. passive immunization
D. adequate hydration
E. anti-inflammatory medications

I got this one right, but still don't get it.

A healthy 6 day old baby girl is brough to the office for her first well baby checkup. This is the mother's second child. She was born full term, with a birth weight of 4200 grams and a length of 51 cm. APGAR scroes were 8 at 1 min and 9 at 5 min. She was recently discharged from the well baby nursery 3 days ago. The baby's blood type is A negative while the mother is B negative. High circulating levels of anti-A antibodies are found in the mother's blood. Hemolysis did not occur in the baby b/c these maternal antiboides are most likely of which class?

A. IgA
B. IgD
C. IgE
D. IgG
E. IgM

1st one is B. Kid has diphtheria and needs the anti-toxin antibodies which is a form of active immunity.
2nd on is E. IgM doesn't cross the placenta. Don't get confused with anti-D IgG.

 

[Silverish]

Poster above is incorrect for the first.
1st one is C. Patient needs first passive immunization, then antibiotics, then you can go ahead with active immunization.

 

[MudPhud20XX]

So can anyone explain why passive not active? I just don't seem to understand the diff. So before the infection, active immunization would be helpful, but once you get infected why not?

 

[Silverish]

Imagine if you're infected with, lets say hepatitis B, you already have an active immune response trying to compensate for all those virons to neutralize. An active vaccination is trying to do just that - promote an immune response to a weaker antigen instead of a full virus. You're not doing much by giving an active vaccination to a person with a disease (*unless its rabies).
Not to mention, depending on the type of vaccine, you could make the condition worse than it already is. If you give a different strain of a certain strain of virus, you're promoting a immune response to a different specific virus than is within the body of the infected host. Now the immune system is trying to work against 2 seemingly infections.

 

[dfib slim]

So can anyone explain why passive not active? I just don't seem to understand the diff. So before the infection, active immunization would be helpful, but once you get infected why not?

Yeah I misspoke. Passive is the introduction of the antitoxin antibodies, not active.