Vasopressin

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Lubdub222

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The plasma osmolality decreases after infusion of:

a. aldosterone
b. ADH
c. angiotensin II
d. parathyroid hormone
e. saline solution

Answer is B--> ADH, why?
 
The osmolality of plasma is closely regulated by anti-diuretic hormone (ADH). In response to even small increases in plasma osmolality (usually rises in plasma sodium), ADH release from the pituitary is increased causing water resorption in the distal tubules and collecting ducts of the kidney and correction of the increased osmolality. The opposite happens in response to a low plasma osmolality with decreased ADH secretion and water loss through the kidneys. Note that ADH is also secreted in response to hypovolaemia and this stimulus will over-ride any response to serum osmolality.
 
but dont aldosterone and angiotensin II do the same thing?

The osmolality of plasma is closely regulated by anti-diuretic hormone (ADH). In response to even small increases in plasma osmolality (usually rises in plasma sodium), ADH release from the pituitary is increased causing water resorption in the distal tubules and collecting ducts of the kidney and correction of the increased osmolality. The opposite happens in response to a low plasma osmolality with decreased ADH secretion and water loss through the kidneys. Note that ADH is also secreted in response to hypovolaemia and this stimulus will over-ride any response to serum osmolality.
 
except PTH all options decrease osmolality.correct me

Aldosterone increases total salt load, which brings water with it osmotically. It has no effect on osmolality. Saline is isomolal and has no effect on osmalality, which is why they use it for basically everything in a medical setting. ADH is the only thing that increases the absorption of free water.
 
Aldosterone increases total salt load, which brings water with it osmotically. It has no effect on osmolality. Saline is isomolal and has no effect on osmalality, which is why they use it for basically everything in a medical setting. ADH is the only thing that increases the absorption of free water.
osmolality decrease by increase in plasma volume.please correct me
 
It makes much much more sense now! Thank you.

Aldosterone increases total salt load, which brings water with it osmotically. It has no effect on osmolality. Saline is isomolal and has no effect on osmalality, which is why they use it for basically everything in a medical setting. ADH is the only thing that increases the absorption of free water.
 
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