FA 2013 says warfarin inhibits factors 2,7,9,10 protein C and S. Uworld says only 2,7,9,10. thoughts? uptodate says to include C and S. Hard to believe uworld omitted information but just wanted to make sure I had it clear 🙂 Thanks .
-
CycleTrack and SDN are teaming up to make medical school admissions more transparent and accessible! Read the announcement to learn how we’re supporting the future of CycleTrack’s free application-tracking tools .
Step I warfarin for VTE prophylaxis
Started by hopeinternist
Get help with your application
Use all the free resources available to you from SDN: articles, guides, expert advising, forums discussions, and school research.
Definitely C and S as well, it's the reason you get warfarin skin necrosis.
UW isn't exactly the bible...in fact if I had to pick between only ONE resource, I'd probably pick FA over UW.
With that said yeah Protein C and S also...one of the few nitty gritty things I remember reading out of Big Guyton's
Also the reason it's good to heparinize a patient for a couple days before giving warfarin...otherwise they can be prone to thromboembolism since without C and S they can't cleave factors 5 and 8.
Last edited:
I thought you give heparin before warfarin because there is a delay in the onset of warfarin's effects, since it is basically affected NEW gamma-carboxylation, and there will still be some active coag factors around; heparin on the other hand goes to work with ATIII immediately. or is it both reasons?
Yea, no you're right, it is both.
Edit: apparently you also only need to wait a couple hours before adding warfarin I said a few days
Last edited:
