What's a good example of a disease with pretty consistent symptomatology?

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neurosciencegal

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Unlike schizophrenia, which has such a wide range of manifestations of symptoms---it's differs on a case by case basis.

But what's a great example of a disease where it's not that different for most patients?
 
down syndrome?

diabetes type 1?
 
Cystic fibrosis & a lot of other monogenic disorders, I would venture.
 
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