Pictorially:
The former is a prodrug of the latter (which is the antinarcoleptic Provigil). The former is hepatotoxic but the latter ain't. So obviously the conversion from hydroxamic acid to acetamide produces a hepatoxic byproduct. What's going on here?

The former is a prodrug of the latter (which is the antinarcoleptic Provigil). The former is hepatotoxic but the latter ain't. So obviously the conversion from hydroxamic acid to acetamide produces a hepatoxic byproduct. What's going on here?