Why does hereditary Fructose intolerance lead to liver damage?

[whatdidigetinto]

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It says in FA and RR biochemistry that it causes liver damage but they don't explain why.

 

[Boardz]

It says in FA and RR biochemistry that it causes liver damage but they don't explain why.

F1phosphate accumulates and inhibits some metabolic ****. says my first aid 2011.

 

[whatdidigetinto]

While studying, I couldn't actually figure out the real reason either but I recall my med school professor stating that it was because of a depletion of phosphate (all of it being tied up in F1P, F --> F1P being a very fast reaction). Depletion of Phosphate --> Decreased ATP --> Cellular Damage. I can't confirm that this is actually true because he didn't cite a source in that lecture but that's how I sort of conceptualized it. Same sort of deal appears to hold for Hereditary Galactose intolerance as well.

Well it makes much more sense when you think about it that way.