why does high level of glucose in blood lead to extreme thirst?

[akimhaneul]

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why?

 

[Mad Jack]

Hyperosmalarity and constant diaresis.

 

[akimhaneul]

Hyperosmalarity and constant diaresis.

Does hyperosmolarity lead to a lot of fluid loss through urine? is that why there is a lot of thirst?

 

[Mad Jack]

Does hyperosmolarity lead to a lot of fluid loss through urine? is that why there is a lot of thirst?

Pretty much. You can only reabsorb so much glucose in the kidneys. Once you exceed that limit, the excess glucose is excreted in urine, and draws water out with it. This leads to volume depletion, which leads to thirst via the RAAS.