Why does lymphatic obstruction lead to edema with exudate?

[whatdidigetinto]

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Where is the protein coming from?

 

[Phloston]

My guess is the protein is coming from the lymph vessels.

With prolonged lymphatic obstruction, you get a dilatation of the lymph vessels, which is called lymphangiectasia. This is also accompanied by surrounding fibrous growth (probably contributing to the non-pitting oedema characteristic of lymphatic obstruction).

Anyway, lymph vessels have fewer tight junctions than blood vessels, so it's likely that with lymphangiectasia, there's a greater propensity for proteinaceous fluid to escape into the interstitium, thereby increasing interstitial oncotic pressure. This increased oncotic pressure then pulls fluid out of the plasma, further exacerbating the oedema.

Milroy disease is congenital lymphangiectasia, which we likely don't need to know for the USMLE, but acquired Elephantiasis, caused by Wuchereria bancrofti, we do need to know.

 

[faisal 2000]

My guess is the protein is coming from the lymph vessels.

With prolonged lymphatic obstruction, you get a dilatation of the lymph vessels, which is called lymphangiectasia. This is also accompanied by surrounding fibrous growth (probably contributing to the non-pitting oedema characteristic of lymphatic obstruction).

Anyway, lymph vessels have fewer tight junctions than blood vessels, so it's likely that with lymphangiectasia, there's a greater propensity for proteinaceous fluid to escape into the interstitium, thereby increasing interstitial oncotic pressure. This increased oncotic pressure then pulls fluid out of the plasma, further exacerbating the oedema.

Milroy disease is congenital lymphangiectasia, which we likely don't need to know for the USMLE, but acquired Elephantiasis, caused by Wuchereria bancrofti, we do need to know.

i do not how increase oncotic pressure pull fluid out from the plasma? as i know increase hydrostatic pressure pulls fluid out of plasma to interstitial fluid and cause edema, while decrease osmotic which is equal oncotic pressure pulls fluid out so it is also cause edema.

which pressure will increased and cause edema in case of liver cirrhosis and CHF ?

 

[RnaPolymerase2]

In Liver cirrhosis you lose protein synthesis especially albumin so this causes decreased oncotic pressure this will lead to edema.

In CHF this is more of blood congestion causing backup pressure so it will be increased hydrostatic pressure.