- Joined
- Jul 30, 2007
- Messages
- 9
- Reaction score
- 0
Thrombolytics is not used for MI?
Why?
- Thread starter miss Dettol
- Start date
- Joined
- Dec 22, 2006
- Messages
- 243
- Reaction score
- 3
The timeframe for use of thrombolytics like tPA in strokes is within 3 hours of onset of symptoms. My guess is that with most patients having an MI, they may not get to the hospital within that time. Look at the patient most frequently having an MI: a bit older male, likely overweight or obese with other commorbid factors such as hypertension, hypercholesterolemia, DM II or decreased insulin sensitivity, and perhaps the reason it takes them longer to show up, GERD. Some people, in fact, may not even have very severe substernal crushing pain.
After that early timeframe, perhaps, there's a risk of reperfusion injury from oxygen free radical formation.
Do a pubmed search however, or look on medline, and you might find differently. There are a handful of recent articles (read: 2007 copyright) that describe the use of thrombolyics in acute STEMI therapy. It would appear that they are warranted, although other agents like clopidogrel and heparin are still rather commonly used. So is angioplasty for reperfusion.
Here's one abstract: http://www.ncbi.nlm.nih.gov/sites/e...ez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
After that early timeframe, perhaps, there's a risk of reperfusion injury from oxygen free radical formation.
Do a pubmed search however, or look on medline, and you might find differently. There are a handful of recent articles (read: 2007 copyright) that describe the use of thrombolyics in acute STEMI therapy. It would appear that they are warranted, although other agents like clopidogrel and heparin are still rather commonly used. So is angioplasty for reperfusion.
Here's one abstract: http://www.ncbi.nlm.nih.gov/sites/e...ez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
- Joined
- Jun 28, 2007
- Messages
- 1,958
- Reaction score
- 10
It depends on the situation you're in.
In my hospital, you'd never give them. You can't turn around without bumping into a cardiologist. If you've show up in the ED with an MI they're pushing those fancy platelet inhibitors and they've got them into the cath lab. In all the research, this is actually better than thrombolytics.
Howeer, if you're in the middle of nowhere with no access to those things, your best bet is to actually give thrombolytics.
In my hospital, you'd never give them. You can't turn around without bumping into a cardiologist. If you've show up in the ED with an MI they're pushing those fancy platelet inhibitors and they've got them into the cath lab. In all the research, this is actually better than thrombolytics.
Howeer, if you're in the middle of nowhere with no access to those things, your best bet is to actually give thrombolytics.
- Joined
- Dec 12, 2006
- Messages
- 3,884
- Reaction score
- 3,661
What the hell are you talking about?
