WTF? Pubmed searches can be fascinating

[yaah]

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Pubmed

This is the article outline:

Constipation is a prevalent medical disorder. Its prevalence is estimated to range from 2% to 28% which imposes a large burden on patients and society. A frequency of less than three stools per week has therefore been widely used to define constipation [1], [2] and [3].

There are different routes to treat constipation including: laxatives, psychological therapy, and biofeedback. Usually constipated patients have mild-moderate symptoms and are self-treated [1]. So an easy and safe way to overcome this problem has important value.

It has shown that the stimulation of glans penis leads to contraction of puborectalis and levator ani muscles which is called ‘peno-motor reflex’ [4]. Another reflex called ‘bulbocavernosus reflex’ refers to anal sphincter contraction in response to squeezing the glans penis [5].

According to the above-mentioned information, it seems that squeezing the glans penis during defecation could result in contraction of anal sphincter, increasing the intra rectal pressure which subsequently stimulates rectal sensory nerves that produce an urge to defecate. So this easy maneuver could improve the defecation process and reduce constipation incidence. Surely, the efficacy of this maneuver should be assessed in clinical trials.


Just thought I would share. Was doing a pubmed search on something related to the penis and pathology and this came up. The article title is perhaps the most brilliant article title I have seen.

Squeezing the glans penis: A possible maneuver for improving the defecation process and preventing constipation

 

[yaah]

Here's another two related "studies". I'd put everyone involved in these studies on a watch list.

pubmed

pubmed

 

[Gut Shot]

Mendizabal MV, Naftalin RJ. Exposure of rat colonic mucosa to human semen in vivo induces mucosal cytolysis, abolishes fluid absorption and raises paracellular permeability. Clin Sci (Lond). 82:277-82, 1992.

 

[Napoleon1801]

Mendizabal MV, Naftalin RJ. Exposure of rat colonic mucosa to human semen in vivo induces mucosal cytolysis, abolishes fluid absorption and raises paracellular permeability. Clin Sci (Lond). 82:277-82, 1992.

Naturally the next question is what kind of applicator was used to get the semen in, and the next being whose semen was it, and why the fook did an IRB approve it.

Who wants to email this to PETA?

 

[ygdrasil]

Pubmed
Squeezing the glans penis: A possible maneuver for improving the defecation process and preventing constipation

That is... wonderful. I'm definitely mentioning this to my oft-stopped-up relation at Winter Holiday Dinner.

 

[SaltySqueegee]

Mendizabal MV, Naftalin RJ. Exposure of rat colonic mucosa to human semen in vivo induces mucosal cytolysis, abolishes fluid absorption and raises paracellular permeability. Clin Sci (Lond). 82:277-82, 1992.

HIV and anal sex transmission?

 

[Gut Shot]

HIV and anal sex transmission?

What's the world coming to when the withdrawal method is applicable to anal sex?

 

[deschutes]

What, no one's mentioned the Journal of Irreproducible Results yet?

Mendizabal MV, Naftalin RJ. Exposure of rat colonic mucosa to human semen in vivo induces mucosal cytolysis, abolishes fluid absorption and raises paracellular permeability. Clin Sci (Lond). 82:277-82, 1992.

What about rat gastric mucosa?

 

[Waywoe]

This is my favorite so far:

Sanyal S, Singh KhD, Kumar P, Kaman L.

Drinking glass in the rectum: a difficult therapeutic problem.
Indian J Gastroenterol. 2003 Nov-Dec;22(6):239-40. No abstract available.



I was looking for a reference related to PCR. Apparently there is more than one Sanyal S writing articles.

 

[yaah]

This is my favorite so far:

Sanyal S, Singh KhD, Kumar P, Kaman L.

Drinking glass in the rectum: a difficult therapeutic problem.
Indian J Gastroenterol. 2003 Nov-Dec;22(6):239-40. No abstract available.

Yeah, but if you click on that citation and ask for "similar results" you get over 100 citations. Many of these related to drinking glasses in the rectum!

OK, this is completely fascinating to me. Try it for yourself. Go to pubmed.com and put in words that aren't relevant to medicine, like "hilarious." If you put in "hilarious" only one citation comes up.


1: Arch Sex Behav. 1994 Oct;23(5):579-97.
Menstrual cycle variation of women's interest in erotica.Zillmann D, Schweitzer KJ, Mundorf N.

Female respondents were given the opportunity to choose feature films for viewing. Choices were made on the basis of synopses and promotional videos. These materials projected (i) a focus on erotic, sexual events, (ii) romantic themes, (iii) action-packed violent drama, and (iv) hilarious comedy. Additionally, respondents evaluated the appeal of the projected films. Respondents' position in the menstrual cycle was then determined, with placement into one of seven 4-day phases. Measured in both choices and evaluations, a postmenstrual surge in erotic interest was evident. Erotic interest was also pronounced prior to and during menses. In contrast, it was at a minimum during the first half of the luteal phase. The choice of romantic films was not appreciably influenced by cycle position. However, in evaluating films with romantic themes, premenstrual women expressed particularly little interest in this genre.

 

[Adrian Cocot]

Wikipedia's list of Ig Nobel Prize Winners.

 

[heartsounds]

i thought id throw this into the mix... the health benefits of swallowing during fellatio.

J Reprod Immunol. 2000 Mar;46(2):155-66. Links
Correlation between oral sex and a low incidence of preeclampsia: a role for soluble HLA in seminal fluid?
Koelman CA, Coumans AB, Nijman HW, Doxiadis II, Dekker GA, Claas FH.
Department of Immunohematology and Blood Bank, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands.

 

[HCE]

i thought id throw this into the mix... the health benefits of swallowing during fellatio.

J Reprod Immunol. 2000 Mar;46(2):155-66. Links
Correlation between oral sex and a low incidence of preeclampsia: a role for soluble HLA in seminal fluid?
Koelman CA, Coumans AB, Nijman HW, Doxiadis II, Dekker GA, Claas FH.
Department of Immunohematology and Blood Bank, Leiden University Medical Centre, PO Box 9600, 2300 RC, Leiden, The Netherlands.

I don't imagine there is any mention of any pending clinic trials?

 

[Matte Kudesai]

Int J STD AIDS. 2006 Nov;17(11):776-8. Title: Self-induced penomegaly. Author: Markos AR. Staffordshire General Hospital, Weston Road, Stafford ST16 3SA, England. Abstract: A 56-year-old Caucasian man applied elastic bands to the penile base to overcome flaccidity of the glans during erection. He continued the practice over 25 years, which lead to lymphoedema, fibrosis and consequently penomegaly. Erection was not compromised otherwise.

 

[HCE]

Int J STD AIDS. 2006 Nov;17(11):776-8. Title: Self-induced penomegaly. Author: Markos AR. Staffordshire General Hospital, Weston Road, Stafford ST16 3SA, England. Abstract: A 56-year-old Caucasian man applied elastic bands to the penile base to overcome flaccidity of the glans during erection. He continued the practice over 25 years, which lead to lymphoedema, fibrosis and consequently penomegaly. Erection was not compromised otherwise.

Isn't that sort of like "Otherwise Mrs. Lincoln, how did you enjoy the play?"

 

[Matte Kudesai]

J Eur Acad Dermatol Venereol. 2006 Oct;20(9):1046-54.
The carcinogenicity of smegma: debunking a myth.

Van Howe RS, Hodges FM.
Department of Pediatrics, Michigan State University School of Human Medicine, Marquette, MI, USA.
BACKGROUND: Smegma is widely believed to cause penile, cervical and prostate cancer. This nearly ubiquitous myth continues to permeate the medical literature despite a lack of valid supportive evidence. METHODS: A historical perspective of medical ideas pertaining to smegma is provided, and the original studies in both animals and humans are reanalysed using the appropriate statistical methods. RESULTS: Evidence supporting the role of smegma as a carcinogen is found wanting. CONCLUSIONS: Assertions that smegma is carcinogenic cannot be justified on scientific grounds.

 

[Matte Kudesai]

1: Anim Reprod Sci. 2007 Feb;97(3-4):237-45. Epub 2006 Mar 13. Links
Effects of chronic exposure to soy meal containing diet or soy derived isoflavones supplement on semen production and reproductive system of male rabbits.

Cardoso JR, Báo SN.
Institute of Biological Sciences, University of Campinas, Campinas, São Paulo, Brazil. [email protected]
Soy and derivative diets deliver large doses of isoflavones to human and animals throughout their lifespan, including gestation. Epidemiologic and experimental data suggest that the consumption of soybean containing foods may protect against cardiovascular disease and decrease breast, prostate and endometrial cancer risk. Based on animal and in vitro studies, however, concerns have been raised that consumption of isoflavones may cause potential adverse effects on the reproductive tract and behavior. The aim of this study was to investigate the effects of chronic consumption of a soy meal containing diet or soy isoflavones supplement on the morphology of reproductive organs, semen quality, age that males reached puberty, and sexual behavior of male rabbits. With this purpose, 16 female rabbits were randomly assigned to receive: (1) a soy- and alfalfa-free diet; (2) a soy- and alfalfa-free diet supplemented with 5mg/kg body wt./day of soy isoflavones; (3) a soy- and alfalfa-free diet supplemented with 20mg/kg body wt./day of soy isoflavones; (4) a diet containing 18% of soy meal, throughout the gestation and lactation. After weaning, male offspring received the same diet, which was given to the respective mother. The age that males reached puberty, semen characteristics and sexual behavior were evaluated in these animals. At 33 weeks of age, the reproductive organs were submitted to histological evaluation. Rabbits, which received large amounts of isoflavones (20mg/kg body wt./day) had a lesser food intake, body weight and semen volume. Spermatogenesis, morphology of male genital organs and sexual behavior did not differ significantly from the control group. We conclude that chronic dietary treatment with soy based diet or soy isoflavones have no adverse effects on the observed reproductive patterns of male rabbits.

 

[b&ierstiefel]

1: Int J Sports Med. 2007 Sep;28(9):727-31. Epub 2007 Apr 23.Click here to read Links
Red cell and core temperature in spelunking.
Stenner E, Piccinini C, Biasioli B, Gianoli E, Bussani A, Delbello G.

School of Sport Medicine, Faculty of Medicine and Surgery, University of Trieste, Trieste, Italy. [email protected]

Alpine spelunking is practiced in darkness, isolation, cold and high humidity. In this paper we study the acute haematological effects of prolonged strenuous activity in five spelunkers who spent about 20 hours in a 700-meter deep cave without resting much or sleeping. On four occasions, we measured their red cell counts, haemoglobin, mean corpuscular volume and percentage changes of plasma volume. We also measured their rectal temperature to estimate, in the limits of this parameter, thermoregulatory response. After the spelunkers descended 5 hours to the bottom of the cave, we detected, in all of them, a significant increase in red cell counts and haemoglobin and a drop in mean corpuscular volume and plasma volume. The day after recovery, we found a significant drop in all red cell parameters and a rise in plasma volumes. Rectal temperatures peaked at the exit. These findings suggest that alpine spelunking induces an initial haemoconcentration (bottom of the cave) followed by a haemodilution (the day after recovery). Sport anaemia was not detected. The rise of rectal temperature suggests that spelunking is a very strenuous sport with possible transpiration problems.

 

[yaah]

You know, if I was a big name academic pathologist I would almost certainly be doing stuff like this and publishing it. Awesome.

1: Ann Diagn Pathol. 2008 Apr;12(2):98-102. Epub 2007 Oct 24. Links
Applying morphologic techniques to evaluate hotdogs: what is in the hotdogs we eat?Prayson BE, McMahon JT, Prayson RA.
Laurel School.

Americans consume billions of hotdogs per year resulting in more than a billion dollars in retail sales. Package labels typically list some type of meat as the primary ingredient. The purpose of this study is to assess the meat and water content of several hotdog brands to determine if the package labels are accurate. Eight brands of hotdogs were evaluated for water content by weight. A variety of routine techniques in surgical pathology including routine light microscopy with hematoxylin-eosin-stained sections, special staining, immunohistochemistry, and electron microscopy were used to assess for meat content and for other recognizable components. Package labels indicated that the top-listed ingredient in all 8 brands was meat; the second listed ingredient was water (n = 6) and another type of meat (n = 2). Water comprised 44% to 69% (median, 57%) of the total weight. Meat content determined by microscopic cross-section analysis ranged from 2.9% to 21.2% (median, 5.7%). The cost per hotdog ($0.12-$0.42) roughly correlated with meat content. A variety of tissues were observed besides skeletal muscle including bone (n = 8), collagen (n = 8), blood vessels (n = 8), plant material (n = 8), peripheral nerve (n = 7), adipose (n = 5), cartilage (n = 4), and skin (n = 1). Glial fibrillary acidic protein immunostaining was not observed in any of the hotdogs. Lipid content on oil red O staining was graded as moderate in 3 hotdogs and marked in 5 hotdogs. Electron microscopy showed recognizable skeletal muscle with evidence of degenerative changes. In conclusion, hotdog ingredient labels are misleading; most brands are more than 50% water by weight. The amount of meat (skeletal muscle) in most brands comprised less than 10% of the cross-sectional surface area. More expensive brands generally had more meat. All hotdogs contained other tissue types (bone and cartilage) not related to skeletal muscle; brain tissue was not present.

 

[Depakote]

You know, if I was a big name academic pathologist I would almost certainly be doing stuff like this and publishing it. Awesome.

1: Ann Diagn Pathol. 2008 Apr;12(2):98-102. Epub 2007 Oct 24. Links
Applying morphologic techniques to evaluate hotdogs: what is in the hotdogs we eat?Prayson BE, McMahon JT, Prayson RA.
Laurel School.

Americans consume billions of hotdogs per year resulting in more than a billion dollars in retail sales. Package labels typically list some type of meat as the primary ingredient. The purpose of this study is to assess the meat and water content of several hotdog brands to determine if the package labels are accurate. Eight brands of hotdogs were evaluated for water content by weight. A variety of routine techniques in surgical pathology including routine light microscopy with hematoxylin-eosin-stained sections, special staining, immunohistochemistry, and electron microscopy were used to assess for meat content and for other recognizable components. Package labels indicated that the top-listed ingredient in all 8 brands was meat; the second listed ingredient was water (n = 6) and another type of meat (n = 2). Water comprised 44% to 69% (median, 57%) of the total weight. Meat content determined by microscopic cross-section analysis ranged from 2.9% to 21.2% (median, 5.7%). The cost per hotdog ($0.12-$0.42) roughly correlated with meat content. A variety of tissues were observed besides skeletal muscle including bone (n = 8), collagen (n = 8), blood vessels (n = 8), plant material (n = 8), peripheral nerve (n = 7), adipose (n = 5), cartilage (n = 4), and skin (n = 1). Glial fibrillary acidic protein immunostaining was not observed in any of the hotdogs. Lipid content on oil red O staining was graded as moderate in 3 hotdogs and marked in 5 hotdogs. Electron microscopy showed recognizable skeletal muscle with evidence of degenerative changes. In conclusion, hotdog ingredient labels are misleading; most brands are more than 50% water by weight. The amount of meat (skeletal muscle) in most brands comprised less than 10% of the cross-sectional surface area. More expensive brands generally had more meat. All hotdogs contained other tissue types (bone and cartilage) not related to skeletal muscle; brain tissue was not present.

But without the grease you all you can taste is the hog anus.

 

[Sean2tall]

You know, if I was a big name academic pathologist I would almost certainly be doing stuff like this and publishing it. Awesome.

1: Ann Diagn Pathol. 2008 Apr;12(2):98-102. Epub 2007 Oct 24. Links
Applying morphologic techniques to evaluate hotdogs: what is in the hotdogs we eat?Prayson BE, McMahon JT, Prayson RA.
Laurel School.

Darn, the hotdog thing was going to be my contribution to this topic,

 

[Waywoe]

Must have been a slow period in the old lab.

 

[caffeinegirl]

Actually the hot dog study was his daughter's high school science project...and he decided it was good enough for a paper! His interest in it from the neuropath aspect was to verify there was no brain matter in the hot dogs. It was the most popular poster at CAP last year!

 

[Gene_]

Actually the hot dog study was his daughter's high school science project...and he decided it was good enough for a paper! His interest in it from the neuropath aspect was to verify there was no brain matter in the hot dogs. It was the most popular poster at CAP last year!

Somebody did the hot dog thing as a CAP poster last year. It was an interesting poster, probably the most popular one at the conference.

 

[djmd]

Actually the hot dog study was his daughter's high school science project...and he decided it was good enough for a paper! His interest in it from the neuropath aspect was to verify there was no brain matter in the hot dogs. It was the most popular poster at CAP last year!

HA HAHA!

Thats awesome.

That explains the two Prayons and the "Laurel School"

RA Prayson is the same guy who authored The Foundations in Diagnostic Pathology, Neurology
http://www.amazon.com/Neuropathology-Foundations-Diagnostic-Richard-Prayson/dp/0443066582