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The scientists claimed that antibody B offers a better means in preventing organ injury than agents such as free radical and protease inhibitors. Which of the following reasons offers the best support for this claim? (Correct Choice: B)
A. Antibody B is a high affinity antibody; therefore, it will not be rejected by the patient.
B. Antibody B can block the initiation of events that result in the release of harmful, biologically active molecules.
C. Antibody B is a very specific antibody; therefore, it will not recognize anything other than the beta subunit.
D. Antibody B exhibits a high half life and can be used at any dosage at any time.
Passage Details.
In the passage, a discussion of neutrophils and their effects on causing organ damage is discussed. Two membrane proteins, the alpha and beta subunit, binds to the endometrium allowing these leukocytes to migrate toward local tissues. During reperfusion, the adhering leukocytes release radicals, proteases, and prostaglandins. The beta subunit is found to be the main mediator in adhering the cell membrane of the neutrophils to the endometrium, and antibody B binds this particular subunit.
My Thinking Process.
I quickly eliminated choices A and D, and was stuck between B and C. The passage indicated that both radicals and proteases are released from these neutrophils. But wouldn't the choice of using an antibody specific to the beta subunit indicate that the antibody will not prevent other leukocytes' functions, thus specifically inhibiting the leukocytes that cause organ damage but allowing other leukocytes that release useful proteases to maintain their functions in the immune process?
A. Antibody B is a high affinity antibody; therefore, it will not be rejected by the patient.
B. Antibody B can block the initiation of events that result in the release of harmful, biologically active molecules.
C. Antibody B is a very specific antibody; therefore, it will not recognize anything other than the beta subunit.
D. Antibody B exhibits a high half life and can be used at any dosage at any time.
Passage Details.
In the passage, a discussion of neutrophils and their effects on causing organ damage is discussed. Two membrane proteins, the alpha and beta subunit, binds to the endometrium allowing these leukocytes to migrate toward local tissues. During reperfusion, the adhering leukocytes release radicals, proteases, and prostaglandins. The beta subunit is found to be the main mediator in adhering the cell membrane of the neutrophils to the endometrium, and antibody B binds this particular subunit.
My Thinking Process.
I quickly eliminated choices A and D, and was stuck between B and C. The passage indicated that both radicals and proteases are released from these neutrophils. But wouldn't the choice of using an antibody specific to the beta subunit indicate that the antibody will not prevent other leukocytes' functions, thus specifically inhibiting the leukocytes that cause organ damage but allowing other leukocytes that release useful proteases to maintain their functions in the immune process?