- Joined
- May 13, 2016
- Messages
- 77
- Reaction score
- 6
1) Based on the data presented in the passage, which statement best describes the HSP110ΔE9 allele?
I understand the cancer-suppressing part, but don't understand how to figure out that HSP110ΔE9 is dominant to HSP110WT.
3) A man with a CRC mutation that results in the synthesis of HSP110ΔE9 and a woman that does not carry this mutation in any of her tissues have a child. What is the percent chance that the child will inherit the CRC mutation?
I don't understand the explanation AAMC gives about why the gene is somatic and not germ line dependent.
5) The information in the passage best supports the conclusion that Intron 8 of HSP110most likely contains which of the following?
I completely do not understand how to approach this question.
24) Which mechanism best describes how P-gp facilitates drug resistance?
Please let me know if this is how the question should be approached: The passage says P-gp exhibits ATPase activity. This rules out D. Since P-gp is a transporter this rules out A and C. Thus, the answer is B.
26) What is the most likely location of P-gp within the plasma membrane?
Since P-gp (P-glycoprotein) has glycosylated chains I figured that it wouldn't be associated with the lipid bilayer. So I chose C. What about my reasoning is incorrect?
38) The lung cells of heavy smokers would be expected to have greatly increased concentrations of cP-450 and:
I ruled out A because every cell would have DNA sequences that code for cP-450. Ruled out B because mRNA is transient and is degraded easily so you can't have increased concentrations of it. Ruled out C because didn't think rRNA would be specific to each protein that's made. Cys residues were mentioned in the passage so I went with D.
I understand the cancer-suppressing part, but don't understand how to figure out that HSP110ΔE9 is dominant to HSP110WT.
3) A man with a CRC mutation that results in the synthesis of HSP110ΔE9 and a woman that does not carry this mutation in any of her tissues have a child. What is the percent chance that the child will inherit the CRC mutation?
I don't understand the explanation AAMC gives about why the gene is somatic and not germ line dependent.
5) The information in the passage best supports the conclusion that Intron 8 of HSP110most likely contains which of the following?
I completely do not understand how to approach this question.
24) Which mechanism best describes how P-gp facilitates drug resistance?
Please let me know if this is how the question should be approached: The passage says P-gp exhibits ATPase activity. This rules out D. Since P-gp is a transporter this rules out A and C. Thus, the answer is B.
26) What is the most likely location of P-gp within the plasma membrane?
Since P-gp (P-glycoprotein) has glycosylated chains I figured that it wouldn't be associated with the lipid bilayer. So I chose C. What about my reasoning is incorrect?
38) The lung cells of heavy smokers would be expected to have greatly increased concentrations of cP-450 and:
I ruled out A because every cell would have DNA sequences that code for cP-450. Ruled out B because mRNA is transient and is degraded easily so you can't have increased concentrations of it. Ruled out C because didn't think rRNA would be specific to each protein that's made. Cys residues were mentioned in the passage so I went with D.