“Adherer Effect”

[Chrish]

Adherence to candesartan and placebo and outcomes in chronic heart failure in the CHARM programme: double-blind, randomised, controlled clinical trial - PubMed

Good adherence to medication is associated with a lower risk of death than poor adherence in patients with CHF, irrespective of assigned treatment. This finding suggests that adherence is a marker for adherence to effective treatments other than study medications, or to other adherence...

pubmed.ncbi.nlm.nih.gov

https://www.nejm.org/doi/10.1056/NEJM198010303031804?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

Fascinating studies. Mortality rate remains the same in patients with good adherence (> 80%) to either BP/ cholesterol meds or placebo.. It’s not what you take that matters; it’s the adherence to regimen!!

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[Rockinacoustic]

Or perhaps these patients were also highly adherent to their background CHF therapies, thus negating any mortality benefit seen with the study intervention?

 

[Chrish]

However there is a difference between two groups when adherence was poor (< 80%), but not when it was > 80% in 2nd study.