This doesn't cover every nuance but this is what we generally do:
Post-neoadjuvant chemo and mastectomy,
-If pathological partial response or no response, 51 Gy at 1.5 Gy BID followed by boost of 15 Gy BID at 1.5Gy Bid, total of 66 Gy (use 5mm bolus x 15 fractions, more if no erythema)
-If pathologic complete response, then 50 Gy at 2 Gy/fx, followed by 10 Gy boost at 2 Gy per fxn (use 5mm bolus x 15 fractions, more if no erythema)
Long-term followups can see some significant fibrosis with the BID regimen (have sent patients for HBO years after this).
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