Coolio Gamechanger...If I were Sprint, Venom, or Nimbus I'd be Pissed...

[drusso]

Coolio™ has the Potential for Long-Lasting Pain Control

Developed by Brixton Biosciences, Coolio™ therapy is a simple injection intended to result in long lasting desensitization of pain in a targeted area.

www.brixtonbio.com

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[cowboydoc]

Sounds like someone is trying to take us on a fantastic voyage.

 

[MitchLevi]

Website says it lasts 1-2 months?

 

[Orin]

I mean you could just inject alcohol or phenol or any of the other things...but sure. Maybe it'll be amazing

 

[CleanUp]

I didn’t know what orthopedic pain is.

 

[au bon pain]

There can only be one

 

[BobBarker]

I saw Coolio perform at Tumbleweeds in Stillwater, OK. It was fine.

 

[Espn123]

without a doubt this is the best name for a product I’ve ever seen

 

[Doctodd]

There can only be one

View attachment 378391

just realized/read that he died last year of fentanyl OD.

 

[Ferrismonk]

just realized/read that he died last year of fentanyl OD.

Yeah, there can be only one. Coincidence? Looking at you Brixton Biosciences...

 

[SSdoc33]

im going to steer away from any injection that utilizes "cryoslurry"

 

[geauxg8rs]

im going to steer away from any injection that utilizes "cryoslurry"

I prefer all of my slurries hot. And my slushies cold

 

[MitchLevi]

Website says 1-2 months of benefit.

 

[Doctodd]

Website says 1-2 months of benefit.

No it doesn’t. It says 10x local, which is a heck of a lot less. Then it says “potentially up to…” lol

 

[Agast]

I guess “Ice ice baby” didn’t have that je ne sais quoi

 

[Ducttape]

as noted - they are only injecting ice saline slurry.

the only data they have is on the rat model, and there is no evidence this would be helpful in humans or in chronic pain - it was initially studied to see if it could be useful from a preanesthetic standpoint. there is some sort of study regarding cutaneous pain but it is well entrenched behind firewalls in the Journal of Investigative Dermatology.

Results: Ice slurry injection can selectively target the rat sciatic nerve. Being injectable, it can infiltrate around the nerve. The authors demonstrate that a single injection is safe and selective for reversibly disrupting the myelin sheaths and axon density, with complete structural recovery by day 112. This leads to decreased nocifensive function for up to 60 days, with complete recovery by day 112. There was up to median [interquartile range]: 68% [60 to 94%] reduction in mechanical pain response after treatment.

Conclusions: Ice slurry injection selectively targets the rat sciatic nerve, causing no damage to surrounding tissue. Injection of ice slurry around the rat sciatic nerve induced decreased nociceptive response from the baseline through neural selective cryoneurolysis.

 

[SeniorWrangler]

Combination frozen margarita/saline cryoslurry machine in the back room? I love it!

 

[cowboydoc]

I saw Coolio perform at Tumbleweeds in Stillwater, OK. It was fine.

When? I saw him perform at a private party in Aspen circa 2004. He was baaaaaked!

 

[BobBarker]

2004 or 2005

 

[BobBarker]

I saw Sir Mix a Lot at the same venue, same time frame. Can’t remember if it was the same show as Coolio.

 

[cowboydoc]

im going to steer away from any injection that utilizes "cryoslurry"

Sounds like a good way to not have an ice, ice baby.

 

[MitchLevi]

I'm waiting on stem cell ablation injections. You put a commercially available orthobiologic product into a joint and then ablate the joint at 80C and then -180C.