So, question for those who are OK with 1 mg or 2 mg doses of fentanyl as "comfort care" ... are you also OK with chasing that with 50 mg of rocuronium, to avoid distressing family members more than is necessary? Or is that just a little too far over the line?
lol @ rocuronium. Nice one. I've read some of the ICU physicians were/are using versed. I don't know if that's commonplace for super way way end of life care but I also don't think that's a very good drug. If you had just a few minutes left to connect with loved ones in this god forsaken place would you want to receive a drug known to cause anterograde and retrograde amnesia? Seems worse than a massive fentanyl bolus if you ask me. But I assure you it'd get more approval by colleagues, committees, heads of hospitals, etc. Put another way, it's accepted even if someone like me who's thinking through the pharmacology sees it as very inferior given the situation.
I can't tell you what Husel was thinking. The fentanyl doses were huge, no doubt. But as an anesthesiologist what happens when you choose one single agent and forsake all others? You give more of the one tool you choose. If you intubate just on propofol (no paralytic, no benzo, no narcotic) you give more propofol. Maybe a lot more depending on the situation.
Husel picked fentanyl as his end of life med choice apparently. He also apparently cared for a lot of patients who received comfort care, as is natural for an ICU physician. Did he give massive doses to everyone? No. It appears he only did it for an extreme few. What started out as 35 patients got narrowed to 25. That's now at 14. Of the 14, it appears almost all of them had multiple cardiac arrests/multiple rounds of chest compressions and ribs broken. Just curious - if this is your loved one what do you deem an appropriate dose? I know what I'd say - enough. Enough. But definitely not too little - that's the one thing I'd ask.
Maybe his dosing would've been different if he were giving the med himself at bedside, like most anesthesiologists do but isn't commonplace anywhere else ICU included. Maybe he would've done 100-200mcg q 2-3 min until goal reached. I have no idea. All I know is that for a select few patients he chose very large doses. But he didn't do that for everyone, which leads me to believe he had a method to his ways. Maybe he chose 10x the infusion rate for vent tolerance. Maybe 20x. I have no idea.
We often lament on this board the idea that everyone wants to be a physician, but only a few want to put in the work. We're trending towards a health system which allows lots of decision makers, many of them not physicians. Admin gets a say. Nursing gets a voice. Pharmacy gives their opinion. Etc. Husel is being hung out to dry by the system - that's my biggest point here. I really don't see how anyone could see this trial any other way. Husel put the order in. Pharmacy approved. Nursing drew it up and gave it. Not a peep from his director. Nothing from peer review. CMO - silent. All of the people who want a say in how a physician practices or how medical decision making is made - well they've all run for the hills. Leaving this one guy to take the fall. I think it's wrong. And I honestly think he can defend his decision making and I hope he's exonerated. And I hope he sues everyone for defamation and gets $100 mill.
If all I can offer this world is a pressure of 60/30 after my chest gets pumped with multiple rounds of CPR and my ribs broken, body flooded with epi/vaso/levo/versed/fentanyl to sustain such feeble pulsatile flow, my sad state left to rot in my own urine/stool/vomit, pvc sticking out of every orifice God gave me, I only have a couple thoughts -
1) damn it, I did it all wrong
2) i hope my family can get me to a nice steep cliff with a beautiful mountain vista that they can toss me off of and I can enjoy just a few last seconds of freedom
3) please have some mercy and give me a nice solid hefty pour of bourbon/bolus of fentanyl to send me on to the next place. If you tap dance around with 50-100mcg of fentanyl while I struggle with my last few breaths, loved ones surrounding me, then I'll reserve a seat for you in hell.