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- May 13, 2012
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How crazy are the E2 reactions with the stereoselectivity?
I learned from chad's that if you are doing E2, you must grab a hydrogen that is positioned antiperiplanar from the leaving group and if there are two hydrogens that are antiperiplanar then you pick the most substituted carbon(zaitsev)
Now I stumbled upon this video that showed that you have to satisfy the zaitsev's rule first and then antiperiplanar thing by rotating the molecule OR draw the newman projection, etc.
wtf?? I didn't know you have to do that?
http://www.youtube.com/watch?v=O1qyWZEzmyI
I don't understand why he doesn't just grab the hydrogen from the methyl group on the top left corner since it has a hydrogen on a dash position and form the double bond between the carbon thats on the top left corner and the one bearing the br initially.
I learned from chad's that if you are doing E2, you must grab a hydrogen that is positioned antiperiplanar from the leaving group and if there are two hydrogens that are antiperiplanar then you pick the most substituted carbon(zaitsev)
Now I stumbled upon this video that showed that you have to satisfy the zaitsev's rule first and then antiperiplanar thing by rotating the molecule OR draw the newman projection, etc.
wtf?? I didn't know you have to do that?
http://www.youtube.com/watch?v=O1qyWZEzmyI
I don't understand why he doesn't just grab the hydrogen from the methyl group on the top left corner since it has a hydrogen on a dash position and form the double bond between the carbon thats on the top left corner and the one bearing the br initially.