SDN Members don't see this ad. (About Ads) As far as I know, GLUT4 is insulin dependent. However, in Kaplan biochemistry it says as below: "GLUT4 translocation to the cell membrane in skeletal muscle is stimulated by exercise. This effect, which is independent of insulin, involves a 5' AMP-activated kinase." What am I missing here? Why does it say that the effect is independent of insulin? Many thanks in advance.