in which bleeding disorders is coagulation cascade not affected i.e. PT/PTT normal?

[mjmdjd1]

in which bleeding disorders is coagulation cascade not affected i.e. PT/PTT normal? Any way to organize this information and making sense of it instead of straight up memorizing "Immunte thrombocytopenic purpura has normal PT and PTT". You would think that any bleeding state would mean that the coagulation cascade is affected and that PT and PTT will be elevated but obviously that isn't the case.

Thanks

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[Phloston]

PT/aPTT are normal in strict platelet disorders. Such examples would be Glanzmann thrombasthenia and Bernard-Soulier syndrome. Uremic platelet dysfunction is also HY (platelet count normal but bleeding time increased).

vWD has increased aPTT sometimes in addition to bleeding time.

The coagulation cascade has nothing to do with platelets, so ITP wouldn't relate to that.

 

[Slade009]

In simple terms:

Platelet Disorders=
Bleeding Time(BT) increase only

Coagulation Disorders=
PT increases (extrinsic pathway problem)
aPTT increases (intrinsic pathway problem)

Both(Mixed)
1.) DIC= BT increase and PT + aPTT increase
2.) vWD= BT increase with possible increase/normal aPTT
3.) Cirrhosis= BT increase and increase in PT

So far as of my knowledge there isn't anything that decreases PT or aPTT.

Platelet disorders: BSS, GT, ITP and TTP.
Coagulation disorders: Hemophilia A or B and Vit K deficiency.
Mixed: DIC, vWD and Cirrhosis

 

[Jambalayajonny]

EDIT: The user I had replied to got banned for spamming, but I can't delete my post now.