Just had my 3rd year tenure review not too long ago. At an academic medical center. Review went well. I think these are all rules of thumb. I think Ollie is correct, it's not a grant every year, it's having continuous grant funding. But, those are most often, multi-year projects. The valley of death, if you will, in this kind of institution is generally the transition from K award to R01 level. At my institution, the failure rate after having attained a K is 50%. Successful tenure here is two r01s, good publication productivity as defined by numbers and quality of journals/impact as well as senior author papers/lab buildup, international reputation, and teaching evaluations. I am currently on a K. And, I am shotgunning grants. I've applied for 7 in the past year of varying sizes. I have likely my first r01 level funding secured. But, this is a tough game that does have many elements of chance and also political savvy involved. I am not at all confident that I will make it to the next screen on this path. I've always considered my trajectory in the context of acquired skills and not necessarily in titles. Thus, I took what might be considered a somewhat windy path. Neuropsych. 2 year clinical postdoc. 2 year f32. 3 year research assistant professor. Now 3 year tenure track assistant professor. I've been mindful of income. So, as I've gone along the way, I've negotiated well (I think). For example, on the f32, I was paid at a starting faculty level. In considering trajectory, you can kind of play it by ear as far as targeting the big or little pool and clinical and research distributions. As you go a long, it will become more clear where you fit in best. I've published quite a bit and I've had a solid amount of grant funding. I've also tried to take advantage of opportunities to learn about other things. For example, business options. I've considered building a biotech company (I have a few patents submitted) and universities often have resources for learning about stuff like SBIR and STTR mechanisms and also resources to spinoff intellectual property. I have picked some research areas that are hot beds forensically and I have maintained a life support level of clinical activity in order to still be able to spin tales in that realm if I need to pivot at some point. My approach has a cost. I have emphasized flexibility, learning, and trajectory in the context of spinning stories. You have to be able to tell a good story. The cost is focus, time, balance. And, ultimately, say I fail at the tenure track game, maybe I would have been better off dropping clinical activities and keeping to a more narrow path or. . . not taking the big grant, academic medical path and slid into a psychology department that wasn't so aggressive on the grant front in terms of responsibilities. I'm not sure there is a right answer.