I've done it for status epilepticus and in patients with severely elevated ICP (and not a candidate for decompressive hemicraniectomy). For the status patient we started off with pentothal, when that didn't work we tried phenobarbital, when that didn't work we used ketamine. The barbiturates are all cardiac depressants and more importantly also severely depress the immune system. They were all in the NCCU and the neuro CCM guys probably have the most experience. It's no fun at all.