nbme 13 calcium/sarc reticulum question

[abelabbot]

I get the physiology behind this…But I see two different interpretations for this based on discussions posted online…..i think the answer is A, the one with 1 hz, altho its a low frequency, the fact there is contrations + has spaces (meaning calcium gets sequestered back into the sarc reticulum) its therefore the answer….

The last choice with 12 hz and one major contraction looks like tetanus…Am I correct?

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[Apoplexy__]

I get the physiology behind this…But I see two different interpretations for this based on discussions posted online…..i think the answer is A, the one with 1 hz, altho its a low frequency, the fact there is contrations + has spaces (meaning calcium gets sequestered back into the sarc reticulum) its therefore the answer….

The last choice with 12 hz and one major contraction looks like tetanus…Am I correct?

Yeah the answer was 1 Hz. I'm not sure if this was all there was to it, but this was my logic:
Lower frequency --> Fewer voltage-gated Ca2+ opening events --> Less Ca2+ released from sarcoplasmic reticulum --> More Ca2+ left in sarcoplasmic reticulum (more sequestered)

Not sure if 12 Hz was any particular pathology, but calling it tetanus seems feasible. Anything that increases ACh at the Nm receptor too, I would imagine.

 

[abelabbot]

Awesome thank you! Yes I didn't even think of that point…the fact that lower frequency would mean fewer voltage gated ca channels will open up.

 

[abelabbot]

lol @ your "location"