USMLE NBME 18 - Questions and Answers - Discussions & Explanations

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TheAberrantGene

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NBME 18 has been released and is available on regular and extended feedback.
I will be taking it fairly soon as my exam is around the corner.
Let's continue the great trend on this forum and start a discussion once people start taking it,

Best of luck fellas ! :)

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The q about heparin and warfarin for 2 days and no inc of PT time , i don't remember it well but i remember two choices one was " heparin-warfarin effect " and the other " long thrombin half life " ....... Anyone remember this q and what was the answer
 
Another q about a driver has epiplepsy 5 years ago what is your action ..... Was the answer to report him anyway !? Also don't remember it well
 
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A 68 year old man has a serum creatinine of 2.3 mg/dL due to chronically increased hydrostatic pressure in Bowman space. Which of the following disorders is the most likely cause of these finding?

a) BPH
b) Congestive heart failure
c) Hypertension (wrong)
d) Interstitial nephritis
e) Nephrotic syndrome
f) Type 2 diabetes mellitus
 
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A 20 year old woman at 27 weeks' gestation is admitted to the hospital because of a 12-hour history of intense uterine contraction occurring every 8 minutes. Her membranes ruptured 32 hours ago. Her temperature is 102.4F and pulse is 115/min. Physical examination shows tenderness of the uterus. Pelvic examination shows a closed cervix that is not effaced. The fetal heart rate is 210/min. Which of the following is the primary stimulus for her uterine muscle contractions?

a) Decreased myometrial intracellular calcium
b) Direct response to maternal hyperthermia
c) Inflamed maternal decidua release of prostaglandin
d) Maternal adrenocorticosteroid release
e) Stressed fetal production and release of oxytocin (wrong)
 
@Crdioman
1. I can't remember the exact answer but heparin is used in addition to beginning warfarin because of the half lives of coagulation factors II, VII, IX, X... they have to be cleared from the system before an effect is seen since warfarin inhibits vit k epoxidase during the production of coagulation factors. It doesn't affect any of the coagulation factors already present. PT/INR for warfarin, aPTT for heparin.
2. We discussed this one somewhere. Correct answer is he is allowed to drive.

@study03
1. BPH (obstruction ---> increased hydrostatic pressure in BS due to back pressure of urine)
2. C
 
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At autopsy, the heart of a 76-year-old woman shows concentric enlargement of the left ventricle. Microscopic examination of the heart shows enlarged myocardial cells with large nuclei. Which of the following diseases was the most likely cause of the cardiac enlargement?

a) Cardiac amyloidosis
b) Hypertension
c) Hypertrophic cardiomyopathy (wrong)
d) Myocardial infarction
e) Pericarditis
f) South american trypanosomiasis
 
At autopsy, the heart of a 76-year-old woman shows concentric enlargement of the left ventricle. Microscopic examination of the heart shows enlarged myocardial cells with large nuclei. Which of the following diseases was the most likely cause of the cardiac enlargement?

a) Cardiac amyloidosis
b) Hypertension
c) Hypertrophic cardiomyopathy (wrong)
d) Myocardial infarction
e) Pericarditis
f) South american trypanosomiasis

Answer is hypertension. Hypertension increases the pressure within the ventricle, and this pressure overload eventually results in diastolic heart failure, which is associated with concentric enlargement. Myocardial cells hypertrophy and develop "boxcar nuclei" when having to generate increased pressure due to hypertension.
 
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1. a 35 yo woman with infertile, receive injection of contrast material into cervix. on hysterosalpingogram, contrast material also seen in peritoneal cavity, which explain this finding
a) rupture of the fallopian tube
b) rupture of the uterine body
c) spillage of contrast, which an artifact
d) spillage of contrast which normal


2. a man with HIV infection follow up examination, has been treated with HAART for the past 6 years HIV plasma viral load has been undetectable. HIV viral load now increase, antiretroviral resistance suspected. HIV genotype analysis confirms that the virus has resistance mutations, which of the following most likely mutated ? (explanation please, wondering where I should read about this one ?)
a) capsid
b) CD4 and CCR5
c) NEF and Vpr
d) Nucleocapsid and gp41
e) Reverse transcriptase and protease
f) tat and rev
 
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A 68 year old man is brought to the emergency department because of 3-day history of increasingly severe deep chest pain. He also has had shortness of breath, stridor, hoarseness, difficulty swallowing, and a nonproductive cough. He has a long-standing history of hypertension, He has smoked 2 packs of cigarettes daily of 45 years. His temperature is 99F, pulse is 80/min, respirations are 15/min, and blood pressure is 160/94 mmHg. The lungs are clear to auscultation. Physical examination shows a visible pulsation above the manubrium of sternum and displacement of the trachea to the right. A murmur is heard in the second right intercostal space. Which of the following is the most likely diagnosis?

a) aortic bronchitis
b) aortic aneurysm
c) aortic stenosis (wrong)
d) goiter
e) pneumothorax
f) pulmonary regurgitation
 
A 68 year old man is brought to the emergency department because of 3-day history of increasingly severe deep chest pain. He also has had shortness of breath, stridor, hoarseness, difficulty swallowing, and a nonproductive cough. He has a long-standing history of hypertension, He has smoked 2 packs of cigarettes daily of 45 years. His temperature is 99F, pulse is 80/min, respirations are 15/min, and blood pressure is 160/94 mmHg. The lungs are clear to auscultation. Physical examination shows a visible pulsation above the manubrium of sternum and displacement of the trachea to the right. A murmur is heard in the second right intercostal space. Which of the following is the most likely diagnosis?

a) aortic bronchitis
b) aortic aneurysm
c) aortic stenosis (wrong)
d) goiter
e) pneumothorax
f) pulmonary regurgitation

Long-standing history of hypertension and Physical examination shows a visible pulsation ( AORTIC ANEURYSM)
 
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1. a 35 yo woman with infertile, receive injection of contrast material into cervix. on hysterosalpingogram, contrast material also seen in peritoneal cavity, which explain this finding
a) rupture of the fallopian tube
b) rupture of the uterine body
c) spillage of contrast, which an artifact
d) spillage of contrast which normal


2. a man with HIV infection follow up examination, has been treated with HAART for the past 6 years HIV plasma viral load has been undetectable. HIV viral load now increase, antiretroviral resistance suspected. HIV genotype analysis confirms that the virus has resistance mutations, which of the following most likely mutated ? (explanation please, wondering where I should read about this one ?)
a) capsid
b) CD4 and CCR5
c) NEF and Vpr
d) Nucleocapsid and gp41
e) Reverse transcriptase and protease
f) tat and rev

#1 is d) normal spillage of contrast. Definitely not certain on #2 but thinking it might be C, that vaguely rings a bell but I have low confidence about that.
 
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1. a 35 yo woman with infertile, receive injection of contrast material into cervix. on hysterosalpingogram, contrast material also seen in peritoneal cavity, which explain this finding
a) rupture of the fallopian tube
b) rupture of the uterine body
c) spillage of contrast, which an artifact
d) spillage of contrast which normal


2. a man with HIV infection follow up examination, has been treated with HAART for the past 6 years HIV plasma viral load has been undetectable. HIV viral load now increase, antiretroviral resistance suspected. HIV genotype analysis confirms that the virus has resistance mutations, which of the following most likely mutated ? (explanation please, wondering where I should read about this one ?)
a) capsid
b) CD4 and CCR5
c) NEF and Vpr
d) Nucleocapsid and gp41
e) Reverse transcriptase and protease
f) tat and rev

2. I think I put E... the more uworld questions I do the more I can't remember what is where, haha. I know I got it right at least. You might kick yourself after looking at it... but what do the HAART meds inhibit...
 
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1. An experimantal animal is created that has a defect in an innate defense mechanism. Decrease gastric hydrogen chloride production. After 2 months, endoscopic biopsy specimens of gastric fundus and body show decreased mucosal thickness and hyperplasia of enterochromaffin like cell ?
a) Barret esophagus
b) chronic gastriti
c) gastric polyp
d) peptic ulcer
e) whipple disease
f) zolinger ellison syndrome

2. a 12 year old boy is brought to physician by his mother for presport physical examination. his mother is concerned because he is developing an enlarge left brest, and there is family history of breast cancer. his left breast is slightly larger than right brest and nipple mild tender. penis slightly enlarge and pubic hair curling. finding on others PE unremakable. which of the following appropriate next step ?
a) explain that this finding indicate advanced physical development
b) obtain more family history
c) order serum alkaline phosphate and estrogen
d) reassure the mother physical finding not uncommon for his age
e) refer the patient to a specialist in adolescent medicine
 
A 34-year-old man is brought to the emergency department semiconscious and combative. In addition to sedation, a short-acting neuromuscular blocking agent is administered for intubation to prevent aspiration. Within a few seconds after administration of the drug, he has transient muscle fasiculations in his face; he develops generalized paralysis within 1 minute. Forty-five minutes after completion of the procedure, he is still paralyzed. A genetic abnormality of which of the following enzymes is most likely cause of his unusually slow recovery from paralysis?

a) angiotensin-converting enzyme
b) choline o-acetyltransferase
c) monoamine oxidase
d) pheylethanolamine N-methyltransferase
e) pseudocholinesterase
f) tyrosine hydroxylase


An investigator is studying epithelial repair in the small intestine of an experimental animal. The plan is to identify the most active cell division. This cell activity is most likely to be found in which of the following regions?

a) Base of the crypt
b) brunner glands
c) peyer patches
d) top of the villi
 
1. An experimantal animal is created that has a defect in an innate defense mechanism. Decrease gastric hydrogen chloride production. After 2 months, endoscopic biopsy specimens of gastric fundus and body show decreased mucosal thickness and hyperplasia of enterochromaffin like cell ?
a) Barret esophagus
b) chronic gastriti
c) gastric polyp
d) peptic ulcer
e) whipple disease
f) zolinger ellison syndrome

2. a 12 year old boy is brought to physician by his mother for presport physical examination. his mother is concerned because he is developing an enlarge left brest, and there is family history of breast cancer. his left breast is slightly larger than right brest and nipple mild tender. penis slightly enlarge and pubic hair curling. finding on others PE unremakable. which of the following appropriate next step ?
a) explain that this finding indicate advanced physical development
b) obtain more family history
c) order serum alkaline phosphate and estrogen
d) reassure the mother physical finding not uncommon for his age
e) refer the patient to a specialist in adolescent medicine
chronic gastritis
reassure physical finding not uncommon for age
 
A 34-year-old man is brought to the emergency department semiconscious and combative. In addition to sedation, a short-acting neuromuscular blocking agent is administered for intubation to prevent aspiration. Within a few seconds after administration of the drug, he has transient muscle fasiculations in his face; he develops generalized paralysis within 1 minute. Forty-five minutes after completion of the procedure, he is still paralyzed. A genetic abnormality of which of the following enzymes is most likely cause of his unusually slow recovery from paralysis?

a) angiotensin-converting enzyme
b) choline o-acetyltransferase
c) monoamine oxidase
d) pheylethanolamine N-methyltransferase
e) pseudocholinesterase
f) tyrosine hydroxylase


An investigator is studying epithelial repair in the small intestine of an experimental animal. The plan is to identify the most active cell division. This cell activity is most likely to be found in which of the following regions?

a) Base of the crypt
b) brunner glands
c) peyer patches
d) top of the villi
e and a
 
1. 63 yo man with mild emphysema has smoked 1 pack for 45 years sudden headache, myalgia and rising temperature. A dry cough develops, with chill and chest pain. Examination of gram stain of sputum disclose neutrophils, but bacteria are no evident. An X-ray of the chest is consistent with severe pneumonia. A culture of sputum is negative, but culture of bronchoscopy specimen on a highly specialized bacteriologic medium yields gram negative rods. The identity of these bacteria is confirmed by staining with specific fluoroscent antibodies. The patient respond therapy with macrolide Ab. The infection acquired from which of the following ?
a) Inhalation of aerosol from an environmental source
b) Inhalation of dust from bird droppings
c) Inhalation of respiratory secretion from an infected animal
d) Inhalation of respiratory secretion from another infected person
e) The patient normal flora

2. A sexually active 32 year old woman has vaginal pain with urination. Pelvic examination show bilateral vesicoulcerative lesions of introitus. Which of the appropriate antimicrobial therapy ?
a) Acyclovir
b) Amoxicillin/ clavulanate
c) Ganciclovir
d) Penicillin
e) Vidarabine

3. To decrease risk for cardiovascular disease, a 24 year old man begins a weight loss diet. BMI 32 kg/m2 . He intends to lose 16 kg (35lb) by limiting his daily caloric intake to 2000 calories. In order to maintain the recommended protein intake 56 g daily, a balanced decrease in carbonhydrate and fat is required (30:55) which of the following best described number of calory that should be provided by fat in this patient diet each day ?
a) 370
b) 430
c) 510
d) 630
e) 740
 
1. 63 yo man with mild emphysema has smoked 1 pack for 45 years sudden headache, myalgia and rising temperature. A dry cough develops, with chill and chest pain. Examination of gram stain of sputum disclose neutrophils, but bacteria are no evident. An X-ray of the chest is consistent with severe pneumonia. A culture of sputum is negative, but culture of bronchoscopy specimen on a highly specialized bacteriologic medium yields gram negative rods. The identity of these bacteria is confirmed by staining with specific fluoroscent antibodies. The patient respond therapy with macrolide Ab. The infection acquired from which of the following ?
a) Inhalation of aerosol from an environmental source
b) Inhalation of dust from bird droppings
c) Inhalation of respiratory secretion from an infected animal
d) Inhalation of respiratory secretion from another infected person
e) The patient normal flora

2. A sexually active 32 year old woman has vaginal pain with urination. Pelvic examination show bilateral vesicoulcerative lesions of introitus. Which of the appropriate antimicrobial therapy ?
a) Acyclovir
b) Amoxicillin/ clavulanate
c) Ganciclovir
d) Penicillin
e) Vidarabine

3. To decrease risk for cardiovascular disease, a 24 year old man begins a weight loss diet. BMI 32 kg/m2 . He intends to lose 16 kg (35lb) by limiting his daily caloric intake to 2000 calories. In order to maintain the recommended protein intake 56 g daily, a balanced decrease in carbonhydrate and fat is required (30:55) which of the following best described number of calory that should be provided by fat in this patient diet each day ?
a) 370
b) 430
c) 510
d) 630
e) 740

I got #1 wrong as well. I think the correct answer is A (legionella), but someone please correct me if I am wrong. #2 is acyclovir and #3 is 630 (i believe someone explained the math in a previous post).

56g x 4 cal/g = 224 cal (so he has 2000 - 224 = 1776 left to eat in one day). 630 + 1146 = 1776 and 630/1146 = 30/55
 
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A 47-year-old woman develops an irregular, raised, multicolored dark lesion on the area of her left forearm that is frequently exposed to direct sunlight. Examination of tissue obtained on biopsy shows malignant pigmented cells. Involvement of which of the following skin layers is associated with the greatest risk for an unfavorable prognosis?

a) basement membrane (wrong)
b) epidermis
c) papillary dermis
d) reticular dermis
e) subcutaneous tissue
 
A 35-year-old man is brought to the physician by staff of the group home where he resides because of worsening behaviour for 2 weeks. During the interview, he tells the physician that be believes the CIA is spying on him through his television set. He then reports hearing voices in the hall outside the examination room and states that the CIA now plans to kill him. He appears disheveled with unkempt hair and poor hygiene. He has difficulty answering the physician's questions because he seems to be listening to internal stimuli. Mental status examination of the patient is most likely to shoe which of the following findings?

a) flattened affect
b) inability to state his name
c) inability to write his name
d) lack of orientation to place or time (wrong)
e) long-term memory impairment
 
a 66 yo man with 1 month history of cough and 6 month history of shortness of breath. end inspiratory crackles on auscultation and ct chest shows diffuse reticular opacities more pronounced at periphery and base of the lungs. biopsy shows patchy interstitial fibrosis no granuloma. most likely diagnosis
A) berilliosis
B) cryptogenic organizing pneumonia
C) hypersensitivity pneumonitis
D) idiopathic pulmonary fibrosis
E) sarcoidosis
 
A 47-year-old woman develops an irregular, raised, multicolored dark lesion on the area of her left forearm that is frequently exposed to direct sunlight. Examination of tissue obtained on biopsy shows malignant pigmented cells. Involvement of which of the following skin layers is associated with the greatest risk for an unfavorable prognosis?

a) basement membrane (wrong)
b) epidermis
c) papillary dermis
d) reticular dermis
e) subcutaneous tissue
this one is subcutaneous tissue. the deeper it goes the dangerous it is. its been discussed here before
 
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A 35-year-old man is brought to the physician by staff of the group home where he resides because of worsening behaviour for 2 weeks. During the interview, he tells the physician that be believes the CIA is spying on him through his television set. He then reports hearing voices in the hall outside the examination room and states that the CIA now plans to kill him. He appears disheveled with unkempt hair and poor hygiene. He has difficulty answering the physician's questions because he seems to be listening to internal stimuli. Mental status examination of the patient is most likely to shoe which of the following findings?

a) flattened affect
b) inability to state his name
c) inability to write his name
d) lack of orientation to place or time (wrong)
e) long-term memory impairment
flattened affect. this is schizophrenia.
 
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a 66 yo man with 1 month history of cough and 6 month history of shortness of breath. end inspiratory crackles on auscultation and ct chest shows diffuse reticular opacities more pronounced at periphery and base of the lungs. biopsy shows patchy interstitial fibrosis no granuloma. most likely diagnosis
A) berilliosis
B) cryptogenic organizing pneumonia
C) hypersensitivity pneumonitis
D) idiopathic pulmonary fibrosis
E) sarcoidosis

its idiopathic pulmonary fibrosis
 
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flattened affect. this is schizophrenia.

I got this wrong because I thought Schizophrenia is typically considered after 6 months, and schizophreniform is 1 to 6 months. Less than 1 month is brief psychosis or something?
 
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I wasnt aware the negative symptoms can be associated with all three stages. At least I knew that schizophrenia did but not the other two.
 
I got this wrong because I thought Schizophrenia is typically considered after 6 months, and schizophreniform is 1 to 6 months. Less than 1 month is brief psychosis or something?
i answered this question by excluding everything else. i have my reservations about the duration too, and first aid doesn't go into too much detail maybe someone else can give a better explanation.
 
I got this wrong because I thought Schizophrenia is typically considered after 6 months, and schizophreniform is 1 to 6 months. Less than 1 month is brief psychosis or something?
maybe he is living in a group home because of preexisting condition
 
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Newborn 28 weeks, neonatal respiratory distress syndrome, ABG shows decreased pH, decreased Po2 increased PCO2. A deficiency in which of the following most likely caused the disorder?
A. Diacylglycerol
B. Dipalmitoylphosphatidylcholine
C. Phosphatidylserine
D. Sphingomyelin (wrong)
E. Surfactant protein D.

58 yo man, 4 year history of productive cough and increased sputum. smoker, T 37º, HR 72, RR 18. Physical exam cyanosis, diffuse wheezing. Which of the pulmonary cell types most likely to be abnormal?
A. Alveolar endothelial cells
B. Alveolar macrophages
C. Pseudostratified columnar epithelial cells
D. Type I pneumocytes
E. Type II pneumocytes.

Necrosis type on klebsiella pneumonia.
A. Caseous,
B. Fat
C. Fibrinoid
D. Gangrenous
E. Liquefaction

45 yo HDL cholesterol 50, triglycerides 550, total cholesterol 200. most appropiate drug?
A. Colestipol
B. Ezetimibe
C. Fenofibrate (this?)
D. Orlistat
E. Simvastatin. (wrong)

Patient with porphyria cutanea tarda. Which of the following most likely serves as a precursos to uroporphyrin in this patient?
A. Aspartic acid
B. Hippuric acid
C. Histidine
D. Lysine
E. Pyruvic acid
F. Succinyl CoA (this?)
 
I got this wrong because I thought Schizophrenia is typically considered after 6 months, and schizophreniform is 1 to 6 months. Less than 1 month is brief psychosis or something?

I took it as he has schizophrenia already and his condition was just worsening/uncontrolled since it said group home/worsening behavior.
 
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Newborn 28 weeks, neonatal respiratory distress syndrome, ABG shows decreased pH, decreased Po2 increased PCO2. A deficiency in which of the following most likely caused the disorder?
A. Diacylglycerol
B. Dipalmitoylphosphatidylcholine
C. Phosphatidylserine
D. Sphingomyelin (wrong)
E. Surfactant protein D.

58 yo man, 4 year history of productive cough and increased sputum. smoker, T 37º, HR 72, RR 18. Physical exam cyanosis, diffuse wheezing. Which of the pulmonary cell types most likely to be abnormal?
A. Alveolar endothelial cells
B. Alveolar macrophages
C. Pseudostratified columnar epithelial cells
D. Type I pneumocytes
E. Type II pneumocytes.

Necrosis type on klebsiella pneumonia.
A. Caseous,
B. Fat
C. Fibrinoid
D. Gangrenous
E. Liquefaction

45 yo HDL cholesterol 50, triglycerides 550, total cholesterol 200. most appropiate drug?
A. Colestipol
B. Ezetimibe
C. Fenofibrate (this?)
D. Orlistat
E. Simvastatin. (wrong)

Patient with porphyria cutanea tarda. Which of the following most likely serves as a precursos to uroporphyrin in this patient?
A. Aspartic acid
B. Hippuric acid
C. Histidine
D. Lysine
E. Pyruvic acid
F. Succinyl CoA (this?)

B, C, E, C, F
 
i may have chosen this answer wrong, please correct me if my intended answer is wrong
A 39 yo male with polycystic kidney disease is brought to the phys for followup. 6 mo history of intermittent blood in his urine. temp 37C pulse 100 resp 24 BP 160/90 and serum creatinine is 8mg/dl. ABG on room air?
PH pCO2 HCO3
A) 7.22 28 11 (is this the answer? )
B) 7.32 64 32
C) 7.38 40 23
D) 7.46 19 13 ( wrong)
E) 7.49 50 37
please explain. thanks
 
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i may have chosen this answer wrong, please correct me if my intended answer is wrong
A 39 yo male with polycystic kidney disease is brought to the phys for followup. 6 mo history of intermittent blood in his urine. temp 37C pulse 100 resp 24 BP 160/90 and serum creatinine is 8mg/dl. ABG on room air?
PH pCO2 HCO3
A) 7.22 28 11 (is this the answer? )
B) 7.32 64 32
C) 7.38 40 23
D) 7.46 19 13 ( wrong)
E) 7.49 50 37
please explain. thanks

I got it right, as far as I can remember it's A, because he is in renal failure so pH should be low or at the most normal (out D,E), metabolic acidosis (out B), tachypneic so pCO2 should be low (out C), not 100% sure but thats probably the way I saw it.
 
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can anyone explain this one?
 

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can anyone explain this one?
my version of explanation. diuretic (furosemide) not causing diuresis. look at Na+. this means either blood is not going to the kidneys or the kidneys themselves not filtering, so increase in urea nitrogen and creatinine leads to prerenal azotemia
 
in anti cancer drug mediated myelosuppression which of the following needs to be monitored?
A) cytotoxic T cells
B) neutrophils
C) serum complement conc
D) serum immune globulin conc

is the answer B ?
 
in anti cancer drug mediated myelosuppression which of the following needs to be monitored?
A) cytotoxic T cells
B) neutrophils
C) serum complement conc
D) serum immune globulin conc

is the answer B ?

Yup, any type of chemo that causes myelosuppression you want to monitor for neutropenia.
 
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an experimental animal is created that has a defect in an innate gastrointestinal defense mechanism. organism is found to have decreased HCl prod. After 2 months on biopsy gastric fundus and body show decreased mucosal thickness and hyperplasia of enterochromaffin like cells. this closely resembles
A) barrett
B) chronic gastritis (is this the answer)
C) gastric polyp
D)peptic ulcer disease
E) whipple
F) zollinger ellison
 
Hi everyone! i am new on this forum. i just took the NBME 18 (my first one) i have a couple of questions i need help with..... If anyone knows thanks in advance :)


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I may not be correct on all of them but here are my answers
1 c
2 e
3 a
4 a
5 b
6 a
 
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A 48 yo woman with gradual onset of back pain. Xray shows two lytic lesions one on t10 and other on l1. All diagnostic tests are negative
A. Avn
B. Metastatic ca breast
C. Osteosarcoma
D. Renal osteodystrophy
E. Thyroid ca

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