yes! And in the past 5 years I have only had one case where I have been absolutely convinced that the SRI did something. 200mg sertraline in a patient w/ tetrabenazine-induced depression. The patient did not know he was taking an antidepressant. I started the trial as the patient was extreme distraught, tearful, prone to crying and wailing spells, and having suicidal thoughts. After about 8weeks on the drug and a few weeks at 200mg the patient was for the first time sitting in a chair, reading, and smiling. He told me he still felt depressed but wasn't as bothered by it anymore. He didn't know he was on the drug, and his social and medical situation hadn't change and he was still taking the tetrabenazine.
Other than that I have never been able to convince myself that SRI responses I have seen are more than placebo. It's nice to see patients respond marvellously to homeopathic doses of zoloft after a week in the primary care clinic I consult in. Not that I'm knocking the placebo effect. If anything, we should look at how we can maximize these effects in clinical practice. It's indisputable that the majority of response is placebo effect if you look at the RCTs and systematic review. This is why drug companies are devoting large sums to try and do something about the pesky placebo effect that makes their drugs look bad, including advocating for the end of placebo-controlled trials as "unethical". What is a matter of debate is whether any additional difference is a factor of SRIs having more efficacy in severe depressive states (which seems unlikely) vs placebo being less effective with more depressive states (which has been reported for many years), whether SRIs are "active placebos" vs "inert placebos", whether the participants in clinical trial are too well to benefit from SRIs etc.
I had more faith in the TCAs and MAOIs but there is some suggestion that you just get an active placebo effect because of the terrible side-effects. Also the power of MAOIs "if you eat cheese - you'll die!" may also convey something about the powerful therapeutic properties of the drug.
Really wish there was a lot more research on placebo effects, both clinically, psychologically, and neurobiologically. The stuff I've read is pretty fascinating